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Levels of Soluble Endothelium Adhesion Molecules and Complications among Sickle Cell Disease Patients in Ghana

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dc.contributor.author Antwi-Boasiako, Charles
dc.contributor.author Donkor, Eric S.
dc.contributor.author Sey, Fredericka
dc.contributor.author Dzudzor, Bartholomew
dc.contributor.author Otu, Kate H
dc.contributor.author . Dale, Campbell A
dc.contributor.author Ekem, Ivy
dc.date.accessioned 2021-03-26T10:57:37Z
dc.date.available 2021-03-26T10:57:37Z
dc.date.issued 2018-04
dc.identifier.uri http://hdl.handle.net/123456789/5186
dc.description.abstract Abstract: Background: Soluble adhesion molecules are involved in the gathering and joining of inflammatory cells to vascular endothelium. Therefore, they serve as potential markers of endothelial dysfunction in vascular diseases including sickle cell disease (SCD). In Ghana, there are scarcely any report on the levels of adhesion molecules among SCD patients. The current study aimed to determine plasma levels of ICAM-1, VCAM-1 and E-Selectin as markers of endothelial dysfunction in SCD patients in steady state, complications and controls. Methodology: This was a cross-sectional study involving 60 HbAA controls, 46 HbSS steady state, 57 HbSS VOC, 18 HbSC VOC, 21 HbSS with leg ulcer and 11 HbSS with priapism. Blood samples were collected from all the study subjects (n = 213) and processed into plasma. The plasma levels of VCAM-1, ICAM-1 and E-Selectin concentrations of SCD patients and controls were measured using a double sandwich ELISA technique. Demographic information was also collected from the study subjects. Results: Levels of all soluble proteins (ICAM-1, VCAM-1 and E-Selectin) were significantly higher in HbSS steady-state patients compared to non-SCD controls (p < 0.001). Generally, SCD patients with complications had relatively higher levels of the soluble proteins compared to those in the steady-state. Of the SCD patients with complications, those with vaso-occlusion crisis (HbSS VOC) had relatively higher levels of ICAM-1, VCAM-1 and E-Selectin at (62.42 ng/mL 26.09), (634.99 ng/mL 324.31) and (236.77 ng/mL 114.40) respectively; Conclusion: Although levels of adhesion molecules were high in all the SCD patients with complications, those with vaso-occlusive crisis had higher levels. This might reflect an ongoing endothelial dysfunction in these patients. SCD patients with vaso-occlusive crisis presents with a more severe pathophysiology condition. en_US
dc.language.iso en en_US
dc.subject sickle cell disease en_US
dc.subject endothelial dysfunction en_US
dc.subject soluble adhesion molecules en_US
dc.subject E-Selectin en_US
dc.title Levels of Soluble Endothelium Adhesion Molecules and Complications among Sickle Cell Disease Patients in Ghana en_US
dc.type Article en_US


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