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Anti-Nociceptive Synergism of Pregabalin and Xylopic acid Co-administration in Paclitaxel-induced Neuropathy: Isobolographic Analysis

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dc.contributor.author Ofori, Ameyaw Elvis
dc.contributor.author Woode, Eric
dc.contributor.author Kyei, Samuel
dc.contributor.author Biny, Peter Robert
dc.contributor.author Boampong, Johnson Nyarko
dc.date.accessioned 2022-06-06T10:43:11Z
dc.date.available 2022-06-06T10:43:11Z
dc.date.issued 2015-08
dc.identifier.issn 23105496
dc.identifier.uri http://hdl.handle.net/123456789/8277
dc.description 7p:, ill. en_US
dc.description.abstract Paclitaxel-induced neuropathy still remains a clinical problem for patients undergoing chemotherapy. Objective: The objective of the study was to determine the interaction between xylopic acid and pregabalinco-administration as well as their toxicity in paclitaxel-induced neuropathy. Materials and Methods: Neuropathic pain was induced in rats with 2 mg/kg of paclitaxel on four alternate days (days 0, 2, 4 and 6). Equi effective doses of xylopic acid and pregabalin that produced 50% anti-nociception (ED50) were determined from their log-dose response curves in the cold allodynia and thermal pain tests. Xylopic acid and pregabalin were again administered to rats in a fixed ratio combination (1:1) of their ED50’s in order to determine the experimental ED50 (Zexp) of the co-administered compounds. Isobolograms were constructed to compare the Zexp to a theoretical ED50 (Zadd). Blood samples from the various treatment groups of rats were collected for toxicological assessment of the co-administered compounds. Results: The Zexp lay below the Zadd on the isobologram of the cold allodnia test. The co-administration exhibited additivity in the thermal pain test. The co-administration did not produce significant (p>0.05) toxicity in rats. The co-administration may be beneficial in paclitaxel-induced neuropathy. en_US
dc.language.iso en en_US
dc.publisher University of Cape Coast en_US
dc.subject Isobolograms en_US
dc.subject Neuropathic pain en_US
dc.subject Paclitaxel en_US
dc.title Anti-Nociceptive Synergism of Pregabalin and Xylopic acid Co-administration in Paclitaxel-induced Neuropathy: Isobolographic Analysis en_US
dc.type Article en_US


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