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Evidence of Insulin Resistance in Adult Uncomplicated Malaria: Result of a Two-Year Prospective Study

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dc.contributor.author Acquah, Samuel
dc.contributor.author Boampong, Johnson Nyarko
dc.contributor.author Eghan Jnr, Benjamin Ackon
dc.contributor.author Eriksson, Magdalena
dc.date.accessioned 2022-07-07T10:18:03Z
dc.date.available 2022-07-07T10:18:03Z
dc.date.issued 2014-12
dc.identifier.issn 23105496
dc.identifier.uri http://hdl.handle.net/123456789/8425
dc.description 9p:, ill. en_US
dc.description.abstract The study aimed at investigating the effects of adult uncomplicated malaria on insulin resistance. Fasting levels of blood glucose (FBG), glycosylated hemoglobin (HbA1c), and serum insulin were measured in 100 diabetics and 100 age-matched controls before and during Plasmodium falciparum malaria. Insulin resistance and beta cell function were computed by homeostatic models assessment of insulin resistance (HOMAIR) and beta cell function (HOMAB) formulae, respectively. Body mass index (BMI) was computed. At baseline, diabetics had significantly (𝑃 < 0.05) higher levels of BMI, FBG, HbA1c, and HOMAIR but lower level of HOMAB than controls. Baseline insulin levels were comparable (𝑃 > 0.05) between the two study groups. During malaria, diabetics maintained significantly (𝑃 < 0.05) higher levels of BMI, FBG, and HbA1c but lower levels of insulin and HOMAB than controls. Malaria-induced HOMAIR levels were comparable (𝑃 > 0.05) between the two study groups but higher than baseline levels. Apart from BMI and HOMAB, mean levels of all the remaining parameters increased in malaria-infected controls. In malaria-infected diabetics, significant (𝑃 < 0.05) increase was only observed for insulin and HOMAIR but not the other measured parameters. Uncomplicated malaria increased insulin resistance in diabetics and controls independent of BMI. This finding may have implications for the evolution of T2DM in malaria-endemic regions. en_US
dc.language.iso en en_US
dc.publisher University of Cape Coast en_US
dc.title Evidence of Insulin Resistance in Adult Uncomplicated Malaria: Result of a Two-Year Prospective Study en_US
dc.type Article en_US


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