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Autophagy in the control and pathogenesis of parasitic infections

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dc.contributor.author Ghartey‑Kwansah, George
dc.contributor.author Adu‑Nti, Frank
dc.contributor.author Aboagye, Benjamin
dc.contributor.author Ankobil, Amandus
dc.contributor.author Essuman, Edward Eyipe
dc.contributor.author Opoku, Yeboah Kwaku
dc.contributor.author Abokyi, Samuel
dc.contributor.author Abu, Emmanuel Kwasi
dc.contributor.author Boampong, Johnson Nyarko
dc.date.accessioned 2023-10-25T10:03:48Z
dc.date.available 2023-10-25T10:03:48Z
dc.date.issued 2020
dc.identifier.uri http://hdl.handle.net/123456789/9998
dc.description.abstract Background: Autophagy has a crucial role in the defense against parasites. The interplay existing between host autophagy and parasites has varied outcomes due to the kind of host cell and microorganism. The presence of autophagic compartments disrupt a significant number of pathogens and are further cleared by xenophagy in an autolysosome. Another section of pathogens have the capacity to outwit the autophagic pathway to their own advantage. Result: To comprehend the interaction between pathogens and the host cells, it is significant to distinguish between starvation-induced autophagy and other autophagic pathways. Subversion of host autophagy by parasites is likely due to differences in cellular pathways from those of ‘classical’ autophagy and that they are controlled by parasites in a peculiar way. In xenophagy clearance at the intracellular level, the pathogens are first ubiquitinated before autophagy receptors acknowledgement, followed by labeling with light chain 3 (LC3) protein. The LC3 in LC3-associated phago‑ cytosis (LAP) is added directly into vacuole membrane and functions regardless of the ULK, an initiation complex. The activation of the ULK complex composed of ATG13, FIP200 and ATG101causes the initiation of host autophagic response. Again, the recognition of PAMPs by conserved PRRs marks the first line of defense against pathogens, involving Toll-like receptors (TLRs). These all important immune-related receptors have been reported recently to regulate autophagy. Conclusion: In this review, we sum up recent advances in autophagy to acknowledge and understand the interplay between host and parasites, focusing on target proteins for the design of therapeutic drugs. The target host proteins on the initiation of the ULK complex and PRRs-mediated recognition of PAMPs may provide strong potential for the design of therapeutic drugs against parasitic infections. en_US
dc.language.iso en en_US
dc.publisher Cell & Bioscience en_US
dc.subject Autophagy, en_US
dc.subject Autophagosome, en_US
dc.subject Parasitophorous vacuole, en_US
dc.subject Xenophagy, en_US
dc.subject PAAR​ en_US
dc.title Autophagy in the control and pathogenesis of parasitic infections en_US
dc.type Article en_US


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