Determination of Liver Volume Model of an Adult Ghanaian From Some Selected Health Centers for Clinical Applications and Dose Optimization

Abstract

ABSTRACT This thesis considered a flexible two-stage statistical approach to multi-task modeling of multivariate physiological vital signs using GP regression, in which the joint use of nonparametric and Bayesian GP regression methods are ex- plored. In the first stage, nonparametric schemes based on expected value con- tribution statistics for fusing multiple physiological vital signs observed over common time-stamps into a composite vital sign are developed. In the second stage, an appropriate Bayesian Gaussian process regression model is developed for the fused vital sign trajectory in relation to the common observation time- stamps. The relationship existing among the multiple vital signs and available non-time-dependent covariates is modeled with the aid of OGK statistics via the covariance function of the assumed GP. Both Variational Bayes and MCMC methods are developed for parameter inference. The coupling of density-based data fusing methods and GP modeling allowed automated extreme value control within both the response and predictor spaces; response dimension reduction; data reduction in the response space and principled modeling of smoothness of the physiological trend. Using both simulation and real data application, the utility of the proposals is illustrated. In terms of fusing of multivariate vital signs, results show that the probability distribution-based features provide a rich source of appealing functional features with the natural ability to ensure that ex- treme observations are utilized with their effects controlled automatically. For the GP modeling of fused vital signs, the results show that both VB and MCMC algorithms exhibit better fitting performance in terms of MSFE, MAFE, and SMAFE. Thus, the double-stage modeling approach exhibits a great potential for handling multi-task GP regression within the single-task GP framework.