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Now showing items 1-20 of 94

Species abundance and insecticide resistance of Anopheles gambiaein selected areas of Ghana and Burkina Faso

Yawson, A. E.; `Mccall, P. J.; M. D. Wilson, M. D.; Donnelly, M. J. (University of Cape Coast, 2004)

Insecticide-treated materials as a key strategy for malaria control. We report on a survey of the distribution of the molecular forms of Anopheles ambiae Giles (Diptera: Culicidae) and insecticide resistance (the kdr ...
A cis-regulatory sequence driving metabolic insecticide resistance in mosquitoes: Functional characterization and signatures of selection

Wilding ., C.S; Smith I; Lynd A.; A.E., Yawson; D., Weetman; Paine, M.J.I.; M.J., Donnelly (University of Cape Coast, 2008)

Although cytochrome P450 (CYP450) enzymes are frequently up-regulated in mosquitoes resistant to insecticides, no regulatory motifs driving these expression differences with relevance to wild populations have been identified. ...
Field-caught permethrin-resistant anopheles ambiae overexpress cyp6p3, a p450 that metabolises Pyrethroids

Muller, Pie; Warr, Emma; Stevenson, Bradley J.; Pignatelli, Patricia M.; Morgan, John C.; Steven, Andrew; Yawson, Alexander E.; Mitchell, Sara N.; Mitchell, Sara N.; Ranson, Hilary; Hemingway, Janet; Donnelly, Martin J. (University of Cape Coast, 2008-11-28)

Insects exposed to pesticides undergo strong natural selection and have developed various adaptive mechanisms to survive. Resistance to pyrethroid insecticides in the malaria vector Anopheles gambiae is receiving increasing ...
Levels Of serum alanine/aspartate aminotransferase and urea in apparently healthy rural community In Ghana: A case study in sabin-akrofrom and trede in the Ashanti Region

Boampong, J.N.; Acquah, S.; Mate-Siakwa, P.; Mensah, D. Osei-Bonsu; Nyarko, A. (University of Cape Coast, 2009)

Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and urea levels were assessed in 27 males (mean age 32.33 yrs) and in 34 females (mean age 27.85yrs) Ghanaian rural dwellers to determine the functional ...
Predonation testing of potential blood donors for hepatitis B virus infection: approach to blood safety in Cape Coast, Ghana

Acheampong, D. O.; Afoakwah, R.; Boampong, J. N.; Boamponsem, L. K.; Nwaefuna, E. K.; Azuma, E. D. (University of Cape Coast, 2011)

Blood transfusions carry risks of untoward reactions, including the transmission of infections, such as hepatitis B. But about 50% of these blood donors and blood recipients have had natural exposure to hepatitis B virus ...
An evolutionary Account of GPI Anchored Proteins

Man, Ashutosh; Singh, Swati; Dwivedi, Manish; Tripathi, Vijay; Gupta, Dwijendra K (University of Cape Coast, 2011)

GPI anchors consist of three parts; protein, glycan and the phospholipids. The GPI anchored proteins work as cell surface hydrolases, protozoal antigens, adhesion molecules, mammalian antigens and involved in other significant ...
Feeding frequency and survival of Anopheles ambiae in a rice-growing area in Ghana

C h a r l w o o d, J. D.; T o m a s, E. V.; E g y i r - Y a w s o n, A.; K a m p a n g o, A. A.; P i t t s, R. J. (University of Cape Coast, 2011)

Mortality rates, determined by dissection, of predominantly M form female Anopheles gambiae (Diptera: Culicidae) were estimated. Mosquitoes were collected in tent traps and light traps in an irrigation project village in ...
Studies on the behaviour of peridomestic and endophagic M form Anopheles gambiae from a rice growing area of Ghana

Charlwood, J.D.; Tomás, E.V.E.; Salgueiro, P.; Egyir-Yawson, A.; Pitts, R.J.; Pinto, J. (University of Cape Coast, 2011)

The ‘paddy paradox’, the occurrence of large populations of vectors but low amounts of malaria transmission where irrigated rice is grown, was investigated in a village in Ghana where M form Anopheles ambiae are common. ...
Identifcation and validation of a gene causing cross-resistance between insecticide classes in Anopheles ambiae from Ghana

Mitchell, Sara N.; Stevenson, Bradley J.; Müller, Pie; Wilding, Craig S.; Egyir-Yawson, Alexander; Field, Stuart G.; Hemingway, Janet; Paine, Mark J. I.; Ranson, Hilary; Donnelly, Martin James (University of Cape Coast, 2012)

In the last decade there have been marked reductions in malaria incidence in sub-Saharan Africa. Sustaining these reductions will rely upon insecticides to control the mosquito malaria vectors. We report that in the primary ...
Geographic population structure of the African malaria vector Anopheles gambiae suggests a role for the forest-savannah biome transition as a barrier to gene flow

Pinto, J; Egyir-Yawson, A; Vicente, J L; Gomes, B; Santolamazza, F; Moreno, M; Charlwood, J D; Simard, F; Elissa, N; Weetman, D; Donnelly, M J; Caccone, A; Della, Torre A (University of Cape Coast, 2012)

The primary frotropical malaria mosquito vector Anopheles ambiae sensu stricto has a complex population structure. In West Africa, this species is split into two molecular forms and displays local and regional variation ...
Analgesic effects of stem bark extracts of Trichilia monadelpha (Thonn.) JJ De Wilde

Woode, Eric; Amoh-Barimah, Ama Kyeraa; Abotsi, Wonder Kofi Mensah; Ainooson, George Kwaw; Owusu, George (University of Cape Coast, 2012)

Objectives: Various parts of Trichilia monadelpha (Thonn) JJ De Wilde (Fam. Meliaceae) are used in Ghanaian traditional medicine for the treatment of painful and inflammatory conditions. The present study examined the ...
Local delivery of T-bet shRNA reduces inflammation in collagen II‑induced arthritis via down regulation of IFN-γ and IL-17

Xue, Yuan; Yang, Yong; Su, Zhaoliang; Barnie, Prince Amoatt; Zheng, Dong; Zhang, Yun; Xu, Yan; Wang, Shengjun; Xu, Huaxi (University of Cape Coast, 2013)

Abstract.Th1 and Th17 cells are involved in the pathogenesis of rheumatoid arthritis (RA). T-bet, a Th1-specifc transcription factor, appears to drive the maturation of Th1 and IFN-γ secretion. In the present study, we ...
High prevalence of PfCRTK76T mutationin Plasmodium falciparum isolates in Ghana

Afoakwah, Richmond; Boampong, Johnson N.; Egyir-Yawson, Alexander; Nwaefuna, Ekene K.; Verner, Orish N.; Asare, Kwame K. (University of Cape Coast, 2013)

Plasmodium falciparum has successfully developed resistance to almost allcurrently used antimalarials. A single nucleotide polymorphism in the P. falciparum chloroquine resistance transporter (Pfcrt) gene at position 76 ...
Exogenous high-mobility group box 1 inhibits apoptosis and promotes the proliferation of Lewis cells via rage/tlr4-dependent signal pathways

Xu, X.; Zhu, H.; Wang, T.; Sun, Y.; Ni, P.; Liu, Y.; Tian, S.; Barnie, P. Amoah; Shen§, H.; Xu, W.; Xu, H.; Su, Z. (University of Cape Coast, 2013)

Upregulated high-mobility group box 1 (HMGB1) has been found in many diseases. Nevertheless, the function of HMGB1 on modulating the proliferation of lung cancer cells (Lewis cells) and inhibiting apoptosis is poorly ...
Distribution of Hairs on the phalanges of hands among Ghanaians

Aboagye, Benjamin; Tsegah, Korantema Mawuena; Ussif, Abdala Mumuni (University of Cape Coast, 2013)

Aim. Te study intended to observe the frequency and pattern of distribution of phalangeal hairs on the hands of Ghanaians. Material and methods. A total of 1040 healthy consenting individuals (529 females and 511 males) ...
Acetylcholinesterase (Ace-1) target site mutation 119S is strongly diagnostic of carbamate and organophosphate resistance in Anopheles gambiae s.s. and nopheles coluzzii across southern Ghana

Essandoh, John; Yawson, Alexander E; Weetman, David (University of Cape Coast, 2013)

Background : With high DDT resistance present throughout much of West Africa, carbamates and organophosphates are increasingly important alternatives to pyrethroids for indoor residual spraying (IRS). Hough less widespread, ...
Review: Improving our knowledge of male mosquito biology in relation to genetic control programs

Lees, Rosemary Susan; Knols, Bart; Bellini, Romeo; Benedict, Mark Q.; Bheecarry, Ambicadutt; Bossin, Hervé Christophe; Chadee, Dave D.; Charlwood, Jacques; Dabiréi, Roch K.; Djogbenou, Luc; Egyir-Yawson, Alexander; Gato, René; Gouagna, Louis Clément; Hassann, Mo’awia Mukhtar; Khano, Shakil Ahmed; Koekemoer, Lizette L.; Lemperiere, Guy; Manoukis, Nicholas C.; Mozuraitiss, Raimondas; Pitts, R. Jason; Simard, Frederic; Gilles, Jeremie R.L. (University of Cape Coast, 2013)

The enormous burden placed on populations worldwide by mosquito-borne diseases, most notably malaria and dengue, is currently being tackled by the use of insecticides sprayed in residences or applied to bed nets, and in ...
Microscopic identification of possible Clonorchis/Opisthorchis infection in two Ghanaian women with undiagnosed abdominal discomfort: two case reports

Asare, Kwame Kumi; Boampong, Johnson Nyarko; Ameyaw, Elvis Ofori; Thomford, Ama Kyeraa; Afoakwah, Richmond; Thomford, Ama Kyeraa; Kwakye-Nuako, Godwin; Thomford, Kwesi Prah; Quashie, Neils Ben (University of Cape Coast, 2014)

The impact of foodborne trematode infections is gaining recognition worldwide. Clonorchiasis and opisthorchiasis are some of the most neglected tropical foodborne diseases that pose a significant threat to human health. ...
Infection risk factors associated with seropositivity for Toxoplasma gondii in a population-based study in the Central Region, Ghana

Abu, E. K.; Boampong, J. N.; Ayi, I.; Afoakwah, R.; Nsiah, P.; Blay, E. (University of Cape Coast, 2014)

About 20–90% of the world’s population has had contact with Toxoplasma gondii parasites. The aim of this study was to determine the seroprevalence and risk factors associated with T. gondii infection in the Central Region, ...
Immunopathogenesis of myocarditis: he interplay between cardiac fibroblast cells, dendritic cells, macrophages and cd4+t cells

Amoah, B. Prince; Yang, H.; Zhang, P.; Su, Z.; Xu, H. (University of Cape Coast, 2014)

The myocardium responds to aetiologically different athological injuries through a common multistep rocess involving highly co-ordinated interactions between cardiac and immune cells. Cardiac fibroblast cells which constitute ...

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