Nonparametric Stepwise Procedure for Identification of Maximum Safe Dose (MSD)

dc.contributor.author	Adjabui, Michael J.
dc.contributor.author	Howard, Nathaniel K.
dc.contributor.author	Luguterah, Albert 2017
dc.date.accessioned	2021-09-08T11:00:06Z
dc.date.available	2021-09-08T11:00:06Z
dc.date.issued	2017-09-21
dc.identifier.issn	23105496
dc.identifier.uri	http://hdl.handle.net/123456789/6065
dc.description	12p:, ill.	en_US
dc.description.abstract	In this article we consider identification of maximum safe dose (MSD) in a dose response study for distribution-free endpoints. Where the maximum safe dose is the highest dose level that does not exceed the median toxicity of the zero dose by a predetermined margin. A nonparametric confidence set-based approach was proposed, that is we incorporate Mann-Whitney method with the partitioning principle in a step-down fashion for safety evaluation. A comprehensive study of the familywise error rate for our new procedure was compared with the dose response (DR) procedure via a Monte Carlo simulations. An example from preclinical trial in genetic toxicology was used for illustrative purpose	en_US
dc.language.iso	en	en_US
dc.publisher	University of Cape Coast	en_US
dc.subject	Maximum safe dose	en_US
dc.subject	Partitioning principle	en_US
dc.subject	Distribution-free endpoint	en_US
dc.subject	Family wise error rate	en_US
dc.subject	Confidence set	en_US
dc.title	Nonparametric Stepwise Procedure for Identification of Maximum Safe Dose (MSD)	en_US
dc.type	Article	en_US