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Browsing by Author "Chen, Zhiguo"

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Efficient In Vitro Refolding and Characterization of Major Histocompati- bility Complex Class I-Related Chain Molecules A (MICA) and Natural Killer Group 2 Member D (NKG2D) Expressed in E. coli

Zhao, Xin; Acheampong, Desmond Omane; Wang, Youfu; Tang, Mingying; Xie, Wei; Chen, Zhiguo; Wang, Min; Zhang, Juan (University of Cape Coast, 2015)

Major Histocompatibility Complex class I-related chain molecules A (MICA) and receptor Natural killer group 2 member D (NKG2D) are important mem- brane proteins with immunosurveillance properties which could serve as ...
Efficient In Vitro Refolding and Characterization of Major Histocompatibility Complex Class I-Related Chain Molecules A (MICA) and Natural Killer Group 2 Member D (NKG2D) Expressed in E. coli

Zhao, Xin; Acheampong, Desmond Omane; Wang, Youfu; Tang, Mingying; Xie, Wei; Chen, Zhiguo; Wang, Min; Zhang, Juan (University of Cape Coast, 2018-03)

Major Histocompatibility Complex class I-related chain molecules A (MICA) and receptor Natural killer group 2 member D (NKG2D) are important membrane proteins with immunosurveillance properties which could serve as ...
Generation and characterization of a novel human IgG1 antibody against vascular endothelial growth factor receptor 2

Xei, Wei; Li, Daojuan; Zhang, Juan; Li, Zhike; Acheampong, Desmond Omane; He, Yuan; Wang, Youfu; Chen, Zhiguo; Wang, Min (University of Cape Coast, 2014-05-10)

VEGF and its receptors, especially VEGFR2 (KDR), are known to play a critical role in angiogen- esis under both physiological and pathological conditions, including cancer and angiogenic retinopathies. This study was ...
Generation and Characterization of a Novel Human IgG1 Antibody against Vascular Endothelial Growth Factor Receptor 2

Xie, Wei; Li, Daojuan; Zhang, Juan; Li, Zhike; Acheampong, Desmond Omane; He, Yuan; Wang, Youfu; Chen, Zhiguo; Wang, Min (University of Cape Coast, 2014-05)

VEGF and its receptors, especially VEGFR2 (KDR), are known to play a critical role in angiogenesis under both physiological and pathological conditions, including cancer and angiogenic retinopathies. This study was ...
A human IgG-like bispecific antibody co-targeting epidermal growth factor receptor and the vascular endothelial growth factor receptor 2 for enhanced antitumor activity

Chen, Zhiguo; Xie, Wei; Omane Acheampong, Desmond; Xu, Menghuai; He, Hua; Yang, Mengqi; Li, Chenchen; Luo, Chen; Wang, Min; Zhang, Juan (University of Cape Coast, 2016-01-29)

Both Epidermal Growth Factor Receptor (EGFR) and the Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) play critical roles in tumorigenesis. We hypothesized co-targeting EGFR and VEGFR2 using a bispeciﬁc antibody might ...
A Novel Antibody Targeting CD24 and Hepatocellular Carcinoma in Vivo by Near-Infrared Fluorescence Imaging

He, Hua; Tu, Xiaojie; Zhang, Juan; Acheampong, Desmond Omane; Ding, Li; Ma, Zhaoxiong; Ren, Xueyan; Luo, Chen; Chen, Zhiguo; Wang, Tong; Xie, Wei; Wang, Min (University of Cape Coast, 2015)

Liver cancer is one of the most common malignant cancers worldwide. The poor response of liver cancer to chemotherapy has whipped up the interest in targeted therapy with monoclonal antibodies because of its potential ...
A Novel Bispecific Diabody Targeting both Vascular Endothelial Growth Factor Receptor 2 and Epidermal Growth Factor Receptor for Enhanced Antitumor Activity

Xu, Menghuai; Jin, Haizhen; Chen, Zhiguo; Xie, Wei; Wang, Youfu; Wang, Yang; Wang, Min; Zhang, Juan; Omane Acheampong, Desmond (University of Cape Coast, 2016-02-13)

Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor 2 (VEGFR2) are receptor tyrosine kinases known to play critical roles in the development and progression of tumors. Based on the ...
A Novel Fusion Antibody Exhibits Antiangiogenic Activity and Stimulates NK Cell-mediated Immune Surveillance Through Fused NKG2D Ligand

Acheampong, Desmond Omane; Tang, Mingying; Wang, Youfu; Zhao, Xin; Xie, Wei; Chen, Zhiguo; Tian, Wenzhi; Zhang, Juang (2017-04)

A single-chain variable fragment (scFv) targeting vas- cular endothelial growth factor receptor 2 was previously generated from a phage display library in our laboratory. However, it has shortened half-life and lacks ...
Periplasmic expression optimization of VEGFR2 D3 adopting response surface methodology: Antiangiogenic activity study

Cao, Wanlu; Li, Haixin; Zhang, Juan; Li, Daojuan; Acheampong, Desmond Omane; Chen, Zhiguo; Wang, Min (Elsevier, 2013-05-13)

Vascular endothelial growth factor (VEGF) is one of the most signiﬁcant mediators of angiogenesis, which interacts with a speciﬁc membrane receptor: VEGF receptor 2 (VEGFR2). Studies elsewhere have shown that, a VEGF-blocker ...

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