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Browsing by Author "Dandara, Collet"

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Chemoresistance to Cancer Treatment: Benzo-α-Pyrene as Friend or Foe?

Dzobo, Kevin; Hassen, Naseeha; Senthebane, Dimakatso Alice; Thomford, Nicholas Ekow; Rowe, Arielle; Shipanga, Hendrina; Wonkam, Ambroise; Parker, M. Iqbal; Mowla, Shaheen; Dandara, Collet (Molecules, 2018-04-17)

Abstract: Background: Environmental pollution such as exposure to pro-carcinogens including benzo-α-pyrene is becoming a major problem globally. Moreover, the effects of benzo-α-pyrene (BaP) on drug pharmacokinetics, ...
Fibroblast-Derived Extracellular Matrix Induces Chondrogenic Differentiation in Human Adipose-Derived Mesenchymal Stromal/Stem Cells in Vitro

Dzobo, Kevin; Turnley, Taegyn; Wishart, Andrew; Rowe, Arielle; Kallmeyer, Karlien; van Vollenstee, Fiona A.; Thomford, Nicholas E.; Dandara, Collet; Chopera, Denis; Pepper, Michael S.; Parker, M. Iqbal (International Journal of Molecular Sciences, 2016-08-03)

Mesenchymal stromal/stem cells (MSCs) represent an area being intensively researched for tissue engineering and regenerative medicine applications. MSCs may provide the opportunity to treat diseases and injuries that ...
Genetic Susceptibility for Cervical Cancer in African Populations: What Are the Host Genetic Drivers?

Kuguyo, Oppah; Tsikai, Nomsa; Thomford, Nicholas E.; Magwali, Thulani; Madziyire, Mugove G.; Nhachi, Charles F.B.; Matimba, Alice; Dandara, Collet (OMICS A Journal of Integrative Biology, 2018-11-07)

Human papillomavirus (HPV) is an essential but not a sufficient cervical cancer etiological factor. Cancer promoters, such as host genetic mutations, significantly modulate therapeutic responses and susceptibility. ...
In Vitro Reversible and Time-Dependent CYP450 Inhibition Profiles of Medicinal Herbal Plant Extracts Newbouldia laevis and Cassia abbreviata: Implications for Herb-Drug Interactions

Thomford, Nicholas Ekow; Dzobo, Kevin; Chopera, Denis; Wonkam, Ambroise; Maroyi, Alfred; Blackhurst, Dee; Dandara, Collet (Molecules, 2016-07-07)

This study evaluated the effects of Newbouldia laevis and Cassia abbreviata extracts on CYP450 enzyme activity. Recombinant CYP450 enzyme and fluorogenic substrates were used for evaluating inhibition, allowing the ...
Inhibition of CYP2B6 by Medicinal Plant Extracts: Implication for Use of Efavirenz and Nevirapine-Based Highly Active Anti-Retroviral Therapy (HAART) in Resource-Limited Settings

Thomford, Nicholas E.; Awortwe, Charles; Dzobo, Kevin; Adu, Faustina; Chopera, Denis; Wonkam, Ambroise; Skelton, Michelle; Blackhurst, Dee; Dandara, Collet (Molecules, 2016-02-16)

Highly active antiretroviral therapy (HAART) has greatly improved health parameters of HIV infected individuals. However, there are several challenges associated with the chronic nature of HAART administration. For ...
Not Everyone Fits the Mold: Intratumor and Intertumor Heterogeneity and Innovative Cancer Drug Design and Development

Dzobo, Kevin; Senthebane, Dimakatso Alice; Thomford, Nicholas Ekow; Rowe, Arielle; Dandara, Collet; Parker, M. Iqbal (OMICS A Journal of Integrative Biology, 2018)

Disruptive innovations in medicine are game-changing in nature and bring about radical shifts in the way we un- derstand human diseases, their treatment, and/or prevention. Yet, disruptive innovations in cancer drug design ...
Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition

Thomford, Nicholas E.; Dzobo, Kevin; Chopera, Denis; Wonkam, Ambroise; Skelton, Michelle; Blackhurst, Dee; Chirikure, Shadreck; Dandara, Collet (Pharmaceuticals, 2015)

The most accessible points of call for most African populations with respect to primary health care are traditional health systems that include spiritual, religious, and herbal medicine. This review focusses only on the ...
Promoting Undetectable Equals Untransmittable in Sub-Saharan Africa: Implication for Clinical Practice and ART Adherence

Thomford, Nicholas Ekow; Mhandire, Doreen; Dandara, Collet (International Journal of Environmental Research and Public Health, 2020)

In the last decade, reliable scientific evidence has emerged to support the concept that undetectable viral loads prevent human immunodeficiency virus (HIV). Undetectable equals untransmissible (U = U) is a simple message ...
The Role of Tumor Microenvironment in Chemoresistance: To Survive, Keep Your Enemies Closer

Senthebane, Dimakatso Alice; Rowe, Arielle; Thomford, Nicholas Ekow; Shipanga, Hendrina; Munro, Daniella; Al Mazeedi, Mohammad A. M.; Almazyadi, Hashim A. M.; Kallmeyer, Karlien; Dandara, Collet; Pepper, Michael S.; Parker, M. Iqbal; Dzobo, Kevin (International Journal of Molecular Sciences, 2017-07-21)

Chemoresistance is a leading cause of morbidity and mortality in cancer and it continues to be a challenge in cancer treatment. Chemoresistance is influenced by genetic and epigenetic alterations which affect drug uptake, ...
Wharton’s Jelly-Derived Mesenchymal Stromal Cells and Fibroblast-Derived Extracellular Matrix Synergistically Activate Apoptosis in a p21-Dependent Mechanism in WHCO1 and MDA MB 231 Cancer Cells In Vitro

Dzobo, Kevin; Vogelsang, Matjaz; Thomford, Nicholas E.; Dandara, Collet; Kallmeyer, Karlien; Pepper, Michael S.; Parker, M. Iqbal (Stem Cells International, 2016)

The tumour microenvironment plays a crucial role in tumour progression and comprises tumour stroma which is made up of different cell types and the extracellular matrix (ECM). Mesenchymal stromal cells (MSCs) are part of ...

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