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Browsing by Author "Wang, Shengjun"

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CpG‑oligodeoxynucleotides suppress the proliferation of A549 lung adenocarcinoma cells via toll‑like receptor 9 signaling and upregulation of Runt‑related transcription factor 3 expression

Barnie, Prince Amoah; Zhang, Pan; Lu, Ping; Chen, Xiaobo; Su, Zhaoliang; Wang, Shengjun; Xu, Huaxi (University of Cape Coast, 2014)

The aim of the present study was to investigate the effect of CpG-oligodeoxynucelotides (CpG-ODN) on the proliferation of the A549 human lung adenocarcinoma cell line and the expression of Runt-related transcription factor ...
Down regulation of Runx3 is closely related to the decreased Th1-associated factors in patients with gastric carcinoma

Li, Yazhen; Ji, Xiaoyun; Su, Zhaoliang; Tong, Jia; Xia, Sheng; Chen, Xiaobo; Lu, Ping; Barnie, Prince Amoah; Wang, Shengjun; Huang, Xinxiang; Xu, Huaxi (University of Cape Coast, 2014-10-01)

Abstract Runt-related transcription factor 3 (Runx3) is a tumor-suppressor gene and lays an important role in immune regulation, whose reduced expression may lay an important role in the development and progression of ...
Enhanced circulating ILC2s and MDSCs may contribute to ensure maintenance of Th2 predominant in patients with lung cancer

qWu, Yumin; Yan, Yulan; Su, Zhaoliang; Bie, Qingli; Chen, Xiaobo; Barnie, Prince Amoah; Guo, Qi; Wang, Shengjun; Xu, Huaxi (University of Cape Coast, 2016)

Group 2 innate lymphoid cells (ILC2s) were demonstrated to be involved in the initiation and coordination of type 2 T helper cell (Th2) responses. Myeloid-derived suppressor cells (MDSCs) have received a great deal of ...
The expression of toll-like receptor 8 and its relationship with VEGF and bcl-2 in cervical cancer

Zhang, Yun; Yang, Heng; Barnie, Prince Amoah; Yang, Peifang; Su, Zhaoliang; Chen, Jianguo; Jiao, Zhijun; Lu, Liwei; Wang, Shengjun; Xu, Huaxi (University of Cape Coast, 2014-04-16)

BACKGROUND: Cervical cancer is one of the most common cancers in women worldwide, often associated with the infection of human papillomavirus(HPV). Toll-like receptor 8 (TLR8),a pattern recognition receptor,is involved in ...
Glucocorticoid-Induced Tumor Necrosis Factor Receptor Family-Related Protein Exacerbates Collagen-Induced Arthritis by Enhancing the Expansion of Th17 Cells

Wang, Shengjun; Shi, Ye; Yang, Min; Ma, Jie; Tian, Jie; Chen, Jianguo; Mao, Chaoming; Jiao, Zhijun; Ko, King-Hung; Baidoo, Samuel Essien; Xu, Huaxi; Hua, Zichun; Lu, Liwei (Immunopathology and Infectious Diseases, 2012)

Rheumatoid arthritis (RA), a chronic autoimmune form of inflammatory joint disease, progressively af- fects multiple joints with pathological changes in the synovia, cartilage, and bone. Numerous studies have suggested ...
IL-17B activated mesenchymal stem cells enhance proliferation and migration of gastric cancer cells

Bie, Qingli; Zhang, Bin; Sun, Caixia; Ji, Xiaoyun; Barnie, Prince Amoah; Qi, Chen; Peng, Jingjing; Zhang, Danyi; Zheng, Dong; Zheng, Dong; Su, Zhaoliang; Wang, Shengjun; Xu, Huaxi (University of Cape Coast, 2017-01-27)

Mesenchymal stem cells are important cells in tumor microenvironment. We have previously demonstrated that IL-17B/IL-17RB signal promoted progression of gastric cancer. In this study, we further explored the effect of ...
Increased Frequency of Circulating Follicular Helper T Cells in Patients with Rheumatoid Arthritis

Ma, Jie; Zhu, Chenlu; Ma, Bin; Tian, Jie; Baidoo, Samuel Essien; Mao, Chaoming; Wu, Wei; Chen, Jianguo; Tong, Jia; Yang, Min; Jiao, Zhijun; Xu, Huaxi; Lu, Liwei; Wang, Shengjun (Clinical and Developmental Immunology, 2012)

Follicular helper T (Tfh) cells are recognized as a distinct CD4+ helper T-cell subset, which provides for B-cell activation and production of specific antibody responses, and play a critical role in the development of ...
Infiltration of alternatively activated macrophages in cancer tissue is associated with mdsc and th2 polarization in patients with esophageal cancer

Gao, Jingjing; Wu, Yumin; Su, Zhaoliang; Barnie, Prince Amoah; Jiao, Zhijun; Bie, Qingli; Lu, Liwei; Wang, Shengjun; Xu, Huaxi (University of Cape Coast, 2014-08-21)

Myeloid derived suppressor cells (MDSCs) expand in cancer bearing hosts and contribute to tumor immune evasion. M2 macrophages constitute a major cellular component of cancer-related inflammation. However, the correlation ...
Local delivery of T-bet shRNA reduces inflammation in collagen II‑induced arthritis via down regulation of IFN-γ and IL-17

Xue, Yuan; Yang, Yong; Su, Zhaoliang; Barnie, Prince Amoatt; Zheng, Dong; Zhang, Yun; Xu, Yan; Wang, Shengjun; Xu, Huaxi (University of Cape Coast, 2013)

Abstract.Th1 and Th17 cells are involved in the pathogenesis of rheumatoid arthritis (RA). T-bet, a Th1-specifc transcription factor, appears to drive the maturation of Th1 and IFN-γ secretion. In the present study, we ...
β-Glucan enhances antitumor immune responses by regulating differentiation and function of monocytic myeloid-derived suppressor cells

Tian, Jie; Ma, Jie; Ma, Ke; Guo, Hongye; Baidoo, Samuel Essien; Zhang, Yue; Yan, Jun; Lu, Liwei; Xu, Huaxi; Wang, Shengjun (European Journal of Immunology, 2013)

Myeloid-derived suppressor cells (MDSCs) accumulate in tumor-bearing hosts and play a major role in tumor-induced immunosuppression, which hampers effective immuno- therapeutic approaches. β-Glucans have been reported ...

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