Browsing by Subject "Chloroquine"

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High prevalence of PfCRT K76T mutation in Plasmodium falciparum isolates in Ghana

Afoakwah, Richard; Boampong, Johnson Nyarko; Egyir-Yawson, Alexander; Nwaefuna, Ekene K.; Verner, Orish N.; Asare, Kwame K. (University of Cape Coast, 2014-04)

Plasmodium falciparum has successfully developed resistance to almost all currently used antimalarials. A single nucleotide polymorphism in the P. falciparum chloroquine resistance transporter (Pfcrt) gene at position ...
High prevalence of PfCRTK76T mutationin Plasmodium falciparum isolates in Ghana

Afoakwah, Richmond; Boampong, Johnson N.; Egyir-Yawson, Alexander; Nwaefuna, Ekene K.; Verner, Orish N.; Asare, Kwame K. (University of Cape Coast, 2013)

Plasmodium falciparum has successfully developed resistance to almost allcurrently used antimalarials. A single nucleotide polymorphism in the P. falciparum chloroquine resistance transporter (Pfcrt) gene at position 76 ...
Synergism between Pfcrt and Pfmdr1 genes could account for the slow recovery of chloroquine sensitive Plasmodium falciparum strains in Ghana after chloroquine withdrawal

Asare, Kwame K.; Boampong, Johnson N.; Duah, Nancy O.; Afoakwah, Richmond; Sehgal, Rakesh; Quashie, Neils B. (University of Cape Coast, 2015)

Summary Unlike other countries, the chloroquine resistant marker Pfcrt T76 mutant has remained fairly stable in Ghana several years after official disuse of chloroquine. Certain mutations inPfmdr1may potentiate Pfcrt T76, ...

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