Browsing by Subject "Pfcrt"

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Synergism between Pfcrt and Pfmdr1 genes could account for the slow recovery of chloroquine sensitive Plasmodium falciparum strains in Ghana after chloroquine withdrawal

Asare, Kwame K.; Boampong, Johnson N.; Duah, Nancy O.; Afoakwah, Richmond; Sehgal, Rakesh; Quashie, Neils B. (University of Cape Coast, 2015)

Summary Unlike other countries, the chloroquine resistant marker Pfcrt T76 mutant has remained fairly stable in Ghana several years after official disuse of chloroquine. Certain mutations inPfmdr1may potentiate Pfcrt T76, ...
Use of proscribed chloroquine is associated with an increased risk ofpfcrtT76 mutation in some parts of Ghana

Asare, Kwame K; Boampong, Johnson N; Ameyaw, Elvis O; Sehgal, Rakesh; Quashi, Neils B (University of Cape Coast, 2014)

Background: After years of disuse of chloroquine (CQ) as first-line anti-malarial drug in Ghana, reports from molecular studies conducted in parts of the country indicate varying prevalence of 76 mutation in the pfcrtgene. ...

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