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APOBEC3G Variants and Protection against HIV-1 Infection in Burkina Faso
Compaore, Tegwinde Rebeca
;
Soubeiga, Serge Theophile
;
Ouattara, Abdoul Karim
;
Obiri-Yeboah, Dorcas
;
Tchelougou, Damehan
;
Maiga, Mamoudou
(
2016-01
)
APOBEC3G is a potent inhibitor of HIV-1 replication, and act by deaminating cytidines in uracil on the negative strand of the viral cDNA. In this case-control study, APOBEC3G expression in subjects’ naïve to HAART infected by HIV-1 and the effect of APOBEC3G polymorphism on its expression were evaluated. The results show that the HIV-1 infected carriers of the G minor alleles of the variant rs8177832 had a higher expression of APOBEC3G mRNA than the controls carriers of the G minor allele. APOBEC3G polymorphisms could play an important role in the modulation of the HIV-1 dissemination
Compaore, Tegwinde Rebeca
;
Soubeiga, Serge Theophile
;
Ouattara, Abdoul Karim
;
Obiri-Yeboah, Dorcas
;
Tchelougou, Damehan
;
Maiga, Mamoudou
;
Assih, Maleki
;
Bisseye, Cyrille
;
Bakouan, Didier
;
Compaore, Issaka Pierre
;
Dembele, Augustine
;
Martinson, Jeremy
;
Simpore, Jacques
(
PLOS ONE
,
2016
)
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Author
Compaore, Tegwinde Rebeca (2)
Maiga, Mamoudou (2)
Obiri-Yeboah, Dorcas (2)
Ouattara, Abdoul Karim (2)
Soubeiga, Serge Theophile (2)
Tchelougou, Damehan (2)
Assih, Maleki (1)
Bakouan, Didier (1)
Bisseye, Cyrille (1)
Compaore, Issaka Pierre (1)
... View More
Subject
HIV-1 Infection (2)
APOBEC3G (1)
APOBEC3G Variants (1)
Burkina Faso (1)
Protection (1)
... View More
Date Issued
2016 (2)