Circulating Microrna in Plasma of Cervical Cancer Patients at Some Selected Teaching Hospitals in Ghana

Abstract

Circulating microRNAs (miRNAs) in plasma have emerged as promising biomarkers for various cancers, including cervical cancer. This study investigates the profile of circulating miRNAs in the plasma of cervical cancer patients and their potential role in diagnosis and prognosis. Plasma samples were collected from a cohort of 19 cervical cancer patients and 21 age-matched non-cancerous patients. We identified a panel of differentially expressed miRNAs associated with cervical cancer using quantitative real-time PCR. Notably, miR-27a, and miR-155, exhibited significant upregulation in the patient group compared to non-cancerous patients. Furthermore, receiver operating characteristic (ROC) analysis demonstrated the potential of these miRNAs as biomarkers, with area under the curve (AUC) values exceeding 0.7. Correlation analyses revealed that elevated levels of these miRNAs were associated with advanced clinical stages and poorer overall survival rates. Our findings suggest that circulating miRNAs in plasma could serve as non-invasive biomarkers for cervical cancer, aiding in early diagnosis and personalized treatment strategies. Further validation in larger cohorts is warranted to confirm their clinical utility.