University of Cape Coast Institutional Repository

Browsing SCHOOL OF BIOLOGICAL SCIENCES by Author "Helm, Mark"

Browsing SCHOOL OF BIOLOGICAL SCIENCES by Author "Helm, Mark"

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  • Bioconjugation of small Molecules to rna impedes its recognition by Toll-like receptor 7 
    Hellmuth, Isabell; Freund, Isabel; Schlöder, Janine; Seidu-Larry, Salifu; Thüring, Kathrin; Slama, Kaouthar; Langhanki, Jens; Kaloyanova, Stefka; Eigenbrod, Tatjana; Krumb, Matthias; Röhm, Sandra; Peneva, Kalina; Opatz, Till; Jonuleit, Helmut; Dalpke, Alexander H.; Helm, Mark (University of Cape Coast, 2017-03-24)
    A fundamental mechanism of the innate immune system is the recognition, via extra- and intracellular pattern-recognition receptors, of pathogen-associated molecular patterns. A prominent example is represented by foreign ...
  • A modified guanosine phosphoramidite for click functionalization of RNA on the sugar edge 
    Seidu-Larry, Salifu; Krieg, Bettina; Hirsch, Markus; Helm, Mark; Domingo, Olwen (University of Cape Coast, 2012)
    A propargyl containing guanosine phosphonamidite was synthesized and incorporated into siRNA, enabling click-ligation with an azido fluorophore onto the nucleobase sugar edge. Duplex stability was not affected by labeling ...
  • A multifunctional bioconjugate module for versatile photoaffinity labeling and click chemistry of RNA 
    Kellner, Stefanie; Seidu-Larry, Salifu; Burhenne, Jurgen; Motorin, Yuri; Helm, Mark (University of Cape Coast, 2011)
    A multifunctional reagent based on a coumarin scaffold was developed for derivatization of naive RNA. The alkylating agent N3BC [7-azido-4-(bromomethyl)coumarin], obtained by Pechmann condensation, is selective for uridine. ...

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