• Use of proscribed chloroquine is associated with an increased risk ofpfcrtT76 mutation in some parts of Ghana 

  Asare, Kwame K; Boampong, Johnson N; Ameyaw, Elvis O; Sehgal, Rakesh; Quashi, Neils B (University of Cape Coast, 2014)

  Background: After years of disuse of chloroquine (CQ) as first-line anti-malarial drug in Ghana, reports from molecular studies conducted in parts of the country indicate varying prevalence of 76 mutation in the pfcrtgene. ...
• The prevalence of α-thalassemia and its relation to plasmodium falciparum infection in patients presenting to clinics in two distinct ecological zones in Ghana 

  Ghartey-Kwansah, George; Boampong, Johnson N.; Aboagye, Benjamin; Afoakwah, Richmond; Ameyaw, Elvis O.; Quashie, Neils B. (University of Cape Coast, 2015-10-29)

  Thalassemia and sickle cell disease constitute the most monogenic hemoglobin (Hb) disorders worldwide. Clinical symptoms of a+ -thalassemia (a+ -thal) are related to inadequate Hb production and accumulation of b- ...
• The hydroxyl moiety on carbon one (C1) in the monoterpene nucleus of thymol is indispensable for anti-bacterial effect of thymol 

  Boye, Alex; Addo, Justice Kwaku; Acheampong, Desmond Omane; Thomford, Ama Kyeraa; Asante, Emmanuel; Amoaning, Regina Elorm; Kuma, Dominic Nkwantabisa (University of Cape Coast, 2020)

  Background: Thymol, a natural monoterpene phenol is not only relevant clinically as an anti-microbial, antioxidant and anti-inflammatory agent but also holds the prospect as a natural template for pharmaceutical semi ...
• The expression of toll-like receptor 8 and its relationship with VEGF and bcl-2 in cervical cancer 

  Zhang, Yun; Yang, Heng; Barnie, Prince Amoah; Yang, Peifang; Su, Zhaoliang; Chen, Jianguo; Jiao, Zhijun; Lu, Liwei; Wang, Shengjun; Xu, Huaxi (University of Cape Coast, 2014-04-16)

  BACKGROUND: Cervical cancer is one of the most common cancers in women worldwide, often associated with the infection of human papillomavirus(HPV). Toll-like receptor 8 (TLR8),a pattern recognition receptor,is involved in ...
• The ethanolic leaf extract of alchornea cordifolia (schum. & thonn.) muell. arg inhibits the development of dyslipidaemia and hyperglycaemia in dexamethasone-induced diabetic rats 

  Thomford, Ama Kyeraa; Thomford, Kwesi Prah; Ayertey, Fred; Edoh, Dominic Adotei; Thomford, Kobena Amissah; Ameyaw, Elvis O.; Boampong, J. N.; Enimil, M.; Bioh, S. A. (University of Cape Coast, 2015)

  Poor lipid and glucose regulation increases the risk for the development of major cardiovascular diseases and other organ damage. The study evaluated the serum glucose and lipid lowering effects of the 70% (v /v) ethanolic ...
• The concept, state, roles and management of protected areas in Ghana: a review 

  Adom, Dickson; Umachandran, Krishnan; Asante, Daniel Boamah; Ziarati, Parisa; Sawicka, Barbara (University of Cape Coast, 2018-12-12)

  Protected areas have greatly improved the conservation of biological diversities worldwide. The main objective of this short review was to discuss the concept of protected areas, their categorization as well as their state ...
• Synergism between Pfcrt and Pfmdr1 genes could account for the slow recovery of chloroquine sensitive Plasmodium falciparum strains in Ghana after chloroquine withdrawal 

  Asare, Kwame K.; Boampong, Johnson N.; Duah, Nancy O.; Afoakwah, Richmond; Sehgal, Rakesh; Quashie, Neils B. (University of Cape Coast, 2015)

  Summary Unlike other countries, the chloroquine resistant marker Pfcrt T76 mutant has remained fairly stable in Ghana several years after official disuse of chloroquine. Certain mutations inPfmdr1may potentiate Pfcrt T76, ...
• Studies on the behaviour of peridomestic and endophagic M form Anopheles gambiae from a rice growing area of Ghana 

  Charlwood, J.D.; Tomás, E.V.E.; Salgueiro, P.; Egyir-Yawson, A.; Pitts, R.J.; Pinto, J. (University of Cape Coast, 2011)

  The ‘paddy paradox’, the occurrence of large populations of vectors but low amounts of malaria transmission where irrigated rice is grown, was investigated in a village in Ghana where M form Anopheles ambiae are common. ...
• Storage related haematological and biochemical changes in Plasmodium falciparum infected and sickle cell trait donor blood 

  Doku, Emmanuel Tetteh; Aninagyei, Enoch; Adu, Patrick; Egyir-Yawson, Alexander; Acheampong, Desmond Omane (University of Cape Coast, 2018)

  . Background: In sub-Saharan Africa where sickle cell trait (SCT) and malaria is prevalent, significant proportions of blood donors may be affected by one or more of these abnormalities.The haemato-biochemical ...
• Species abundance and insecticide resistance of Anopheles gambiaein selected areas of Ghana and Burkina Faso 

  Yawson, A. E.; `Mccall, P. J.; M. D. Wilson, M. D.; Donnelly, M. J. (University of Cape Coast, 2004)

  Insecticide-treated materials as a key strategy for malaria control. We report on a survey of the distribution of the molecular forms of Anopheles ambiae Giles (Diptera: Culicidae) and insecticide resistance (the kdr ...
• Socio-Economic impact of fruit flies control in mango production in Ghana, evidence from “Manya Krobo 

  Banson, Kwamina Ewurs; Egyir-Yawson, Alexander (University of Cape Coast, 2014-06-20)

  Mango in Ghana is targeted as the next non-traditional export crop that is expected to fetch the highest foreign exchange for the country than cocoa. However, production and export constraints caused by fruit fly Bactrocera ...
• Sex Differences in the Antidepressant Effects of Ketamine in Animal Models of Depression 

  Adu-Nti, Frank; Ghartey-Kwansah, George; Aboagye, Benjamin (2019-07-19)

  Major depressive disorder (MDD) is the most common psychiatric disease and it affects millions of people across the world. Patients suffering from MDD consistently complain about cognitive disturbances, significantly ...
• Serotonin deficiency increases context-dependent fear learning through modulation of hippocampal activity 

  Waider, Jonas; Popp, Sandy; Mlinar, Boris; Montalbano, Alberto; Bonfglio, Francesco; Aboagye, Benjamin; Thuy, Elisabeth; Kern, Raphael; Thiel, Christopher; Araragi, Naozumi; Svirin, Evgeniy; Schmitt-Böhrer, Angelika G.; Corradetti, Renato; Lowry, Christopher .; Lesch, Klaus-Peter (University of Cape Coast, 2019)

  Brain serotonin (5-hydroxytryptamine, 5-HT) system dysfunction is implicated in exaggerated fear responses triggering various anxiety-, stress-, and trauma-related disorders. However, the underlying mechanisms are not well ...
• Serotonin (5-HT) neuron-specific inactivation of Cadherin-13 impacts 5-HT system formation and cognitive function 

  Forero, Andrea; Ku, Hsing-Ping; Malpartida, Ana Belen; Wäldchen, Sina; Alhama-Riba, Judit; Kulka, Christina; Aboagye, Benjamin; Norton, William H J; Young, Andrew M J; Ding, Yu Qiang; Blum, Robert; Sauer, Markus; Rivero, Olga; Lesch, Klaus-Peter (University of Cape Coast, 2019)

  Genome-wide screening approaches identified the cell adhesion molecule Cadherin-13 (CDH13) as a risk factor for neurodevelopmental disorders, nevertheless the contribution of CDH13 to the disease mechanism remains obscure. ...
• Review: Improving our knowledge of male mosquito biology in relation to genetic control programs 

  Lees, Rosemary Susan; Knols, Bart; Bellini, Romeo; Benedict, Mark Q.; Bheecarry, Ambicadutt; Bossin, Hervé Christophe; Chadee, Dave D.; Charlwood, Jacques; Dabiréi, Roch K.; Djogbenou, Luc; Egyir-Yawson, Alexander; Gato, René; Gouagna, Louis Clément; Hassann, Mo’awia Mukhtar; Khano, Shakil Ahmed; Koekemoer, Lizette L.; Lemperiere, Guy; Manoukis, Nicholas C.; Mozuraitiss, Raimondas; Pitts, R. Jason; Simard, Frederic; Gilles, Jeremie R.L. (University of Cape Coast, 2013)

  The enormous burden placed on populations worldwide by mosquito-borne diseases, most notably malaria and dengue, is currently being tackled by the use of insecticides sprayed in residences or applied to bed nets, and in ...
• Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus 

  Grau-Bové, Xavier; Lucas, Eric; Pipini, Dimitra; Rippon, Emily; van’t Hof, Arjèn; Constant, Edi; Dadzie, Samuel; Egyir-Yawson, Alexander; Essandoh, John; Chabi, Joseph; Djogbénou, Luc; Harding, Nicholas J.; Miles, Alistair; Kwiatkowski, Dominic; Donnelly, Martin J.; Weetman, David (University of Cape Coast, 2020)

  Vector population control using insecticides is a key element of current strategies to prevent malaria transmission in Africa. The introduction of effective insecticides, such as the organophosphate pirimiphos-methyl, is ...
• Relative Susceptibilities of BO Blood Groups of Plasmodium falciparum Malaria in Ghana 

  Afoakwah, Richmond; Aubyn, Edmond; Prah, James; Nwaefuna, Ekene Kwabena; Boampong, Johnson N. (University of Cape Coast, 2015)

  The clinical outcome of falciparum malaria in endemic areas is influenced by erythrocyte polymorphisms including the ABO blood groups. Studies have reported association of ABO blood group to resistance, susceptibility, and ...
• Relating high insecticide residues in larval breeding habitats in urban residential areas to the selection of pyrethroid resistance in anopheles gambiae s.l. (diptera: culicidae) in Akim Oda, Ghana 

  Kudom, Andreas A.; Anane, Leticia N.; Afoakwah, Richmond; Adokoh, Christian K. (University of Cape Coast, 2017)

  The main objective of this study was to assess insecticide contamination in Anopheles breeding habitats in urban residential areas and pyrethroid susceptibility status of mosquitoes found in the habitats. A larval survey ...
• Re-evaluating the efficacy of the aqueous leaf extract of Bridelia ferrugenia and its potential combination with metformin in the management of diabetes mellitus 

  Thomford, Kwesi Prah; Edoh, Dominic Adotei; Sarkodie, Joseph A.; Thomford, Ama Kyeraa; Essuman, Kennedy; Owusu, Derrick (University of Cape Coast, 2015-08-28)

  Herbal medicinal products play a significant role in the management of diabetes and other chronic diseases either as a monotherapy or in combination with allopathic treatments. The hypoglycemic activity of a Ghanaian herbal ...
• Quality of sulfadoxine-pyrimethamine given as antimalarial prophylaxis in pregnant women in selected health facilities in Central Region of Ghana 

  Yeboah, Danny F.; Afoakwah, Richmond; Nwaefuna, Ekene K.; Verner, Orish; Boampong, Johnson N. (University of Cape Coast, 2015)

  The use of sulfadoxine-pyrimethamine (SP) as an intermittent preventive treatment (IPT) against malaria during pregnancy has become a policy in most sub-Sahara African countries and crucially depends on the efcacy of SP. ...

• Use of proscribed chloroquine is associated with an increased risk ofpfcrtT76 mutation in some parts of Ghana 

  Asare, Kwame K; Boampong, Johnson N; Ameyaw, Elvis O; Sehgal, Rakesh; Quashi, Neils B (University of Cape Coast, 2014)

  Background: After years of disuse of chloroquine (CQ) as first-line anti-malarial drug in Ghana, reports from molecular studies conducted in parts of the country indicate varying prevalence of 76 mutation in the pfcrtgene. ...
• The prevalence of α-thalassemia and its relation to plasmodium falciparum infection in patients presenting to clinics in two distinct ecological zones in Ghana 

  Ghartey-Kwansah, George; Boampong, Johnson N.; Aboagye, Benjamin; Afoakwah, Richmond; Ameyaw, Elvis O.; Quashie, Neils B. (University of Cape Coast, 2015-10-29)

  Thalassemia and sickle cell disease constitute the most monogenic hemoglobin (Hb) disorders worldwide. Clinical symptoms of a+ -thalassemia (a+ -thal) are related to inadequate Hb production and accumulation of b- ...
• The hydroxyl moiety on carbon one (C1) in the monoterpene nucleus of thymol is indispensable for anti-bacterial effect of thymol 

  Boye, Alex; Addo, Justice Kwaku; Acheampong, Desmond Omane; Thomford, Ama Kyeraa; Asante, Emmanuel; Amoaning, Regina Elorm; Kuma, Dominic Nkwantabisa (University of Cape Coast, 2020)

  Background: Thymol, a natural monoterpene phenol is not only relevant clinically as an anti-microbial, antioxidant and anti-inflammatory agent but also holds the prospect as a natural template for pharmaceutical semi ...
• The expression of toll-like receptor 8 and its relationship with VEGF and bcl-2 in cervical cancer 

  Zhang, Yun; Yang, Heng; Barnie, Prince Amoah; Yang, Peifang; Su, Zhaoliang; Chen, Jianguo; Jiao, Zhijun; Lu, Liwei; Wang, Shengjun; Xu, Huaxi (University of Cape Coast, 2014-04-16)

  BACKGROUND: Cervical cancer is one of the most common cancers in women worldwide, often associated with the infection of human papillomavirus(HPV). Toll-like receptor 8 (TLR8),a pattern recognition receptor,is involved in ...
• The ethanolic leaf extract of alchornea cordifolia (schum. & thonn.) muell. arg inhibits the development of dyslipidaemia and hyperglycaemia in dexamethasone-induced diabetic rats 

  Thomford, Ama Kyeraa; Thomford, Kwesi Prah; Ayertey, Fred; Edoh, Dominic Adotei; Thomford, Kobena Amissah; Ameyaw, Elvis O.; Boampong, J. N.; Enimil, M.; Bioh, S. A. (University of Cape Coast, 2015)

  Poor lipid and glucose regulation increases the risk for the development of major cardiovascular diseases and other organ damage. The study evaluated the serum glucose and lipid lowering effects of the 70% (v /v) ethanolic ...
• The concept, state, roles and management of protected areas in Ghana: a review 

  Adom, Dickson; Umachandran, Krishnan; Asante, Daniel Boamah; Ziarati, Parisa; Sawicka, Barbara (University of Cape Coast, 2018-12-12)

  Protected areas have greatly improved the conservation of biological diversities worldwide. The main objective of this short review was to discuss the concept of protected areas, their categorization as well as their state ...
• Synergism between Pfcrt and Pfmdr1 genes could account for the slow recovery of chloroquine sensitive Plasmodium falciparum strains in Ghana after chloroquine withdrawal 

  Asare, Kwame K.; Boampong, Johnson N.; Duah, Nancy O.; Afoakwah, Richmond; Sehgal, Rakesh; Quashie, Neils B. (University of Cape Coast, 2015)

  Summary Unlike other countries, the chloroquine resistant marker Pfcrt T76 mutant has remained fairly stable in Ghana several years after official disuse of chloroquine. Certain mutations inPfmdr1may potentiate Pfcrt T76, ...
• Studies on the behaviour of peridomestic and endophagic M form Anopheles gambiae from a rice growing area of Ghana 

  Charlwood, J.D.; Tomás, E.V.E.; Salgueiro, P.; Egyir-Yawson, A.; Pitts, R.J.; Pinto, J. (University of Cape Coast, 2011)

  The ‘paddy paradox’, the occurrence of large populations of vectors but low amounts of malaria transmission where irrigated rice is grown, was investigated in a village in Ghana where M form Anopheles ambiae are common. ...
• Storage related haematological and biochemical changes in Plasmodium falciparum infected and sickle cell trait donor blood 

  Doku, Emmanuel Tetteh; Aninagyei, Enoch; Adu, Patrick; Egyir-Yawson, Alexander; Acheampong, Desmond Omane (University of Cape Coast, 2018)

  . Background: In sub-Saharan Africa where sickle cell trait (SCT) and malaria is prevalent, significant proportions of blood donors may be affected by one or more of these abnormalities.The haemato-biochemical ...
• Species abundance and insecticide resistance of Anopheles gambiaein selected areas of Ghana and Burkina Faso 

  Yawson, A. E.; `Mccall, P. J.; M. D. Wilson, M. D.; Donnelly, M. J. (University of Cape Coast, 2004)

  Insecticide-treated materials as a key strategy for malaria control. We report on a survey of the distribution of the molecular forms of Anopheles ambiae Giles (Diptera: Culicidae) and insecticide resistance (the kdr ...
• Socio-Economic impact of fruit flies control in mango production in Ghana, evidence from “Manya Krobo 

  Banson, Kwamina Ewurs; Egyir-Yawson, Alexander (University of Cape Coast, 2014-06-20)

  Mango in Ghana is targeted as the next non-traditional export crop that is expected to fetch the highest foreign exchange for the country than cocoa. However, production and export constraints caused by fruit fly Bactrocera ...
• Sex Differences in the Antidepressant Effects of Ketamine in Animal Models of Depression 

  Adu-Nti, Frank; Ghartey-Kwansah, George; Aboagye, Benjamin (2019-07-19)

  Major depressive disorder (MDD) is the most common psychiatric disease and it affects millions of people across the world. Patients suffering from MDD consistently complain about cognitive disturbances, significantly ...
• Serotonin deficiency increases context-dependent fear learning through modulation of hippocampal activity 

  Waider, Jonas; Popp, Sandy; Mlinar, Boris; Montalbano, Alberto; Bonfglio, Francesco; Aboagye, Benjamin; Thuy, Elisabeth; Kern, Raphael; Thiel, Christopher; Araragi, Naozumi; Svirin, Evgeniy; Schmitt-Böhrer, Angelika G.; Corradetti, Renato; Lowry, Christopher .; Lesch, Klaus-Peter (University of Cape Coast, 2019)

  Brain serotonin (5-hydroxytryptamine, 5-HT) system dysfunction is implicated in exaggerated fear responses triggering various anxiety-, stress-, and trauma-related disorders. However, the underlying mechanisms are not well ...
• Serotonin (5-HT) neuron-specific inactivation of Cadherin-13 impacts 5-HT system formation and cognitive function 

  Forero, Andrea; Ku, Hsing-Ping; Malpartida, Ana Belen; Wäldchen, Sina; Alhama-Riba, Judit; Kulka, Christina; Aboagye, Benjamin; Norton, William H J; Young, Andrew M J; Ding, Yu Qiang; Blum, Robert; Sauer, Markus; Rivero, Olga; Lesch, Klaus-Peter (University of Cape Coast, 2019)

  Genome-wide screening approaches identified the cell adhesion molecule Cadherin-13 (CDH13) as a risk factor for neurodevelopmental disorders, nevertheless the contribution of CDH13 to the disease mechanism remains obscure. ...
• Review: Improving our knowledge of male mosquito biology in relation to genetic control programs 

  Lees, Rosemary Susan; Knols, Bart; Bellini, Romeo; Benedict, Mark Q.; Bheecarry, Ambicadutt; Bossin, Hervé Christophe; Chadee, Dave D.; Charlwood, Jacques; Dabiréi, Roch K.; Djogbenou, Luc; Egyir-Yawson, Alexander; Gato, René; Gouagna, Louis Clément; Hassann, Mo’awia Mukhtar; Khano, Shakil Ahmed; Koekemoer, Lizette L.; Lemperiere, Guy; Manoukis, Nicholas C.; Mozuraitiss, Raimondas; Pitts, R. Jason; Simard, Frederic; Gilles, Jeremie R.L. (University of Cape Coast, 2013)

  The enormous burden placed on populations worldwide by mosquito-borne diseases, most notably malaria and dengue, is currently being tackled by the use of insecticides sprayed in residences or applied to bed nets, and in ...
• Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus 

  Grau-Bové, Xavier; Lucas, Eric; Pipini, Dimitra; Rippon, Emily; van’t Hof, Arjèn; Constant, Edi; Dadzie, Samuel; Egyir-Yawson, Alexander; Essandoh, John; Chabi, Joseph; Djogbénou, Luc; Harding, Nicholas J.; Miles, Alistair; Kwiatkowski, Dominic; Donnelly, Martin J.; Weetman, David (University of Cape Coast, 2020)

  Vector population control using insecticides is a key element of current strategies to prevent malaria transmission in Africa. The introduction of effective insecticides, such as the organophosphate pirimiphos-methyl, is ...
• Relative Susceptibilities of BO Blood Groups of Plasmodium falciparum Malaria in Ghana 

  Afoakwah, Richmond; Aubyn, Edmond; Prah, James; Nwaefuna, Ekene Kwabena; Boampong, Johnson N. (University of Cape Coast, 2015)

  The clinical outcome of falciparum malaria in endemic areas is influenced by erythrocyte polymorphisms including the ABO blood groups. Studies have reported association of ABO blood group to resistance, susceptibility, and ...
• Relating high insecticide residues in larval breeding habitats in urban residential areas to the selection of pyrethroid resistance in anopheles gambiae s.l. (diptera: culicidae) in Akim Oda, Ghana 

  Kudom, Andreas A.; Anane, Leticia N.; Afoakwah, Richmond; Adokoh, Christian K. (University of Cape Coast, 2017)

  The main objective of this study was to assess insecticide contamination in Anopheles breeding habitats in urban residential areas and pyrethroid susceptibility status of mosquitoes found in the habitats. A larval survey ...
• Re-evaluating the efficacy of the aqueous leaf extract of Bridelia ferrugenia and its potential combination with metformin in the management of diabetes mellitus 

  Thomford, Kwesi Prah; Edoh, Dominic Adotei; Sarkodie, Joseph A.; Thomford, Ama Kyeraa; Essuman, Kennedy; Owusu, Derrick (University of Cape Coast, 2015-08-28)

  Herbal medicinal products play a significant role in the management of diabetes and other chronic diseases either as a monotherapy or in combination with allopathic treatments. The hypoglycemic activity of a Ghanaian herbal ...
• Quality of sulfadoxine-pyrimethamine given as antimalarial prophylaxis in pregnant women in selected health facilities in Central Region of Ghana 

  Yeboah, Danny F.; Afoakwah, Richmond; Nwaefuna, Ekene K.; Verner, Orish; Boampong, Johnson N. (University of Cape Coast, 2015)

  The use of sulfadoxine-pyrimethamine (SP) as an intermittent preventive treatment (IPT) against malaria during pregnancy has become a policy in most sub-Sahara African countries and crucially depends on the efcacy of SP. ...

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