• In Vivo Antiplasmodial, Anti-Inflammatory, and Analgesic Properties, and Safety Profile of Root Extracts of Haematostaphis barteri Hook F. (Anacardiaceae) 

  Boampong, Johnson Nyarko (University of Cape Coast, 2015-10-15)

  Malaria is an endemic disease globally and the conundrum of drug resistance has led to the search for newer antimalarial agents. The root extract of H. barteri was evaluated for antimalarial, analgesic, and anti-inflammatory ...
• In vivo antiplasmodial and in vitro antioxidant properties of stem bark extracts of Haematostaphis barteri 

  Boampong, Johnson Nyarko; karikari, Akua Afryie; Ameyaw, Elvis Ofori (University of Cape Coast, 2015-02-03)

  Objective: To evaluate the antimalarial and antioxidant properties of stem bark extracts of Haematostaphis barteri (H. barteri). Methods: The prophylactic activity of the plant was performed by dosing mice with sulfad ...
• In vitro Cercaricidal Activity of Fractions and Isolated Compounds of Erythrophleum ivorense (Fabaceae) Root Bark against Schistosoma haematobium 

  Armah, Francis A.; Amoani, Benjamin; Henneh, Isaac T.; Dickson, Rita A.; Adokoh, Christian K.; Amponsah, Isaac Kingsley; Adu-Gyamfi, Cecilia; Acheampong, Desmond Omane (University of Cape Coast, 2019-02-15)

  ntroduction: Schistosoma haematobium is one of the species of Schistosoma responsible for schistosomiasis in humans, a major public health problem worldwide. Praziquantel, the most effective drug against all adult stages ...
• In vitro activity of Erythrophleum ivorense extract against the promastigote stage of cutaneous Leishmania parasite, a member of Leishmania (Mundinia) enriettii complex isolates from Ghana 

  Anning, Alberta Serwah; Kwakye-Nuako, Godwin; Ameyaw; Ameyaw, Elvis Ofori; Mosore, Mba-Tihssommah; Asare, Kwame Kumi (University of Cape Coast, 2019-09)

  Background. Cutaneous leishmaniasis causes physical disfigurement and impairment on affected individuals, however, little attention has been paid to it eradication. The situation of this neglected disease is complicated ...
• Investigation of a New Focus of Cutaneous Leishmaniasis in Ghana 

  Kwakye-Nuako, George (University of Cape Coast, 2016-02)

  Leishmaniasis is a disease of significant public health importance, which burdens a number of countries around the world, particularly in the tropics and subtropics. An outbreak of suspected cutaneous leishmaniasis (CL) ...
• Intracytoplasmic expression of IL-6 and IL-17A in circulating CD4+ T cells are strongly associated with and predict disease activity in rheumatoid arthritis: A case-control study in Ghana 

  Sakyi, Samuel Asamoah; Buckman, Tonnies Abeku; Antwi-Berko, Daniel; Yeboah-Mensah, Kwame; Dey, Dzifa; Owiredu, Eddie-Williams; Amoani, Benjamin; Mantey, Richard (University of Cape Coast, 2016)

  Background T cell cytokines play important roles in the development and progression of rheumatoid arthritis (RA). Loss of Th1/Th2 and Th17/Treg balance has been reported in several in ammatory autoimmune diseases. ...
• First isolation of a new species of Leishmania responsible for human cutaneous leishmaniasis in Ghana and classification in the Leishmania enriettii complex 

  Kwakye-Nuako, Godwin; Mosore, Mba-Tihssommah; Duplessis, Christopher; Bates, Michelle D.; Puplampu, Naiki; Mensah-Attipoe, Israel; Desewu, Kwame; Afegbe, Godwin; Asmah, Richard H.; Jamjoom, Manal B.; Ayeh-Kumi, Patrick F.; Boakye, Daniel A.; Bates, Paul A. (University of Cape Coast, 2015-06)

  An active case detection approach with PCR diagnosis was used in the Ho District of the Volta Region, Ghana that identified individuals with active cutaneous leishmaniasis. Three isolates were successfully cultured and ...
• Inhibition of Angiogenesis by Recombinant VEGF Receptor Fragments 

  Ahmadvand, Davoud; Rahbarizadeh, Fatemeh; Iri-Sofla, Farnoush Jafari; Namazi, Gholamreza; Khaleghi, Sepideh; Geramizadeh, Bita; Pasalar, Parvin; Karimi, Hosein; Bakhtiari, Seyed Hamid Aghaee (University of Cape Coast, 2010-07)

  Background: Blocking vascular endothelial growth factor receptor (VEGFR) is a successful approach for inhibiting vascular endothelial growth factor (VEGF) signaling. Small molecules impairing the interaction of VEGF ...
• Inducible nitric oxide synthase 2 promoter polymorphism and malaria disease severity in children in Southern Ghana 

  Dzodzomenyo, Mawuli; Ghansah, Anita; Ensaw, Nana; Dovie, Benjamin; Bimi, Langbong; Quansah, Reginald; Gyan, Ben A.; Gyakobo, Mawuli; Amoani, Benjamin (University of Cape Coast, 2018-08-17)

  Objective We assessed the association of mutant allele frequencies of nitric oxide synthase 2 (NOS2) gene at two SNPs (-954 and -1173) with malaria disease severity in children from a malaria endemic area in Southern ...
• AAV1/2-induced overexpression of A53T-α- synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson’s disease 

  Ip, Chi Wang; Klaus, Laura-Christin; Karikari, Akua A.; Visanji, Naomi P.; Brotchie, Jonathan M.; Lang, Anthony E.; Volkmann, Jens; Koprich, James B. (University of Cape Coast, 2017)

  α-Synuclein is a protein implicated in the etiopathogenesis of Parkinson’s disease (PD). AAV1/2-driven overexpression of human mutated A53T-α-synuclein in rat and monkey substantia nigra (SN) induces degeneration of ...
• Indigenous Medicinal Plants as Biofilm Inhibitors for the Mitigation of Antimicrobial Resistance 

  Ampofo, Elikplim Kwesi; Amponsah, Isaac Kingsley; Asante-Kwatia, Evelyn; Armah, Francis Ackah; Atchoglo, Philip Kobla; Mensah, Abraham Yeboah (University of Cape Coast, 2020-10-24)

  The majority of indigenes in the rural areas of Ghana use herbal medicines for their primary health care. In this study, an ethnobotanical survey was undertaken to document medicinal plants used by traditional healers in ...
• Increased Oxidative Stress and Inflammation Independent of Body Adiposity in Diabetic and Nondiabetic Controls in falciparum Malaria 

  Acquah, Samuel; Boampong, Johnson Nyarko; Eghan Jnr, Benjamin Ackon (University of Cape Coast, 2016-05-05)

  Information on the extent to which oxidative stress and inflammation occur in the presence of falciparum malaria and type 2 diabetes mellitus in the same individual is limited. This study sought to investigate the extent ...
• Impact of Iron Fortification on Anaemia and Iron Deficiency among Pre-school Children Living in Rural Ghana 

  Tchum, Samuel Kofi; Arthur, Fareed; Adu, Bright; Sakyi, Samuel Asamoah; Abubakar, Latifatu Alhassan; Atibilla, Dorcas; Amenga-Etego, Seeba; Oppong, Felix Boakye; Dzabeng, Francis; Amoani, Benjamin; Gyan, Thomas; Poku-Asante, Kwaku (University of Cape Coast, 2009-10-27)

  Micronutrient interventions, principally vitamin A and zinc supplementation for children, and fortification of foods with iron and iodine, are considered the most cost-effective global development efforts. Multiple ...
• Immunologic and virological response to ART among HIV infected individuals at a tertiary hospital in Ghana 

  Obiri -Yeboah, Dorcas; Pappoe, Faustina; Baidoo, Ibrahim; Arthur, Francis; Hayfron-Benjamin, Anna; Essien-Baidoo, Samuel; Kwakye-Nuako, Godwin; Ayisi Addo, Stephen (University of Cape Coast, 2018)

  Background: The need to study the outcome of Antiretroviral Therapy (ART) among Human Immunodeficiency Virus (HIV) infected individuals in Ghana, a sub-Saharan African country crucial in the era of the “Treat All” ...
• IgG Responses to the Plasmodium falciparum Antigen VAR2CSA in Colombia Are Restricted to Pregnancy and Are Not Induced by Exposure to Plasmodium vivax 

  Lopez-Perez, Mary; Larsen, Mads Delbo; Bayarri-Olmos, Rafael; Ampomah, Paulina; Stevenson, Liz; Arévalo-Herrera, Myriam; Herrera, Sócrates; Hviida, Lars (University of Cape Coast, 2018-05-18)

  Clinical immunity to malaria is associated with the acquisition of IgG specific for members of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family of clonally variant antigens on the surface of infected ...
• Identification of Sand Flies (Diptera: Psychodidae) Collected from Cutaneous Leishmaniasis Endemic Focus in the Ho Municipality, Ghana 

  Doe, Edna Dzifa; Kwakye-Nuako, Godwin; Addo, Seth Offei; Egyir-Yawson, Alexander (University of Cape Coast, 2020-09-04)

  Leishmaniasis, is a vector-borne disease transmitted to humans through the bite of infected female sand flies. Active and continuous monitoring of the sand fly is an important aspect of disease control. Thus, the correct ...
• Fibroblast Growth Factor-21 ameliorates hepatic encephalopathy by activating the STAT3-SOCS3 pathway to inhibit activated hepatic stellate cells 

  Opoku, Yeboah Kwaku; Liu, Zhihang; Afrifa, Justice; Kumi, Asare Kwame; Liu, Han; Ghartey-Kwansah, George; Koranteng, Harriet; Jiang, Xinghao; Ren, Guiping; Li, Deshan (University of Cape Coast, 2020-05-04)

  Neurological dysfunction, one of the consequences of acute liver failure (ALF), and also referred to as hepatic encephalopathy (HE), contributes to mortality posing challenges for clinical management. FGF21 has been implicated ...
• Hypotensive effect of an aqueous extract of Heliotropium indicum Linn (Boraginaceae) 

  Koffuor, George Asumeng; Boye, Alex; Ameyaw, Elvis Ofori; Amoateng, Patrick; Abiatey, Alfred K. (University of Cape Coast, 2012-04-02)

  Heliotropium indicum Linn (Boraginaceae) has been used widely in the treatment of hypertension in Ghana. This study therefore was aimed at investigating the effects of an aqueous extract of H. indicum Linn on the heart ...
• Housing Surroundings and Self-reported Cases of Malaria in two Communities in Central Region of Ghana 

  Ampomah, Paulina; Afriyie, James (University of Cape Coast, 2017-12)

  Malaria remains a major health problem in Ghana. Mosquito breeding sites play significant role in malaria infection and transmission, but studies in this area are scanty in Ghana. This study assesses the association between ...
• Household Fuel And Garbage Combustion, Street Vending Activities And Adverse Pregnancy Outcomes 

  Amegah, Adeladza Kofi (University of Cape Coast, 2014)

  Air pollution is a major concern in urban areas of developing countries as a result of industrial expansion and increased vehicular ownership, and in most households due to solid fuel use and garbage burning at home. ...

• In Vivo Antiplasmodial, Anti-Inflammatory, and Analgesic Properties, and Safety Profile of Root Extracts of Haematostaphis barteri Hook F. (Anacardiaceae) 

  Boampong, Johnson Nyarko (University of Cape Coast, 2015-10-15)

  Malaria is an endemic disease globally and the conundrum of drug resistance has led to the search for newer antimalarial agents. The root extract of H. barteri was evaluated for antimalarial, analgesic, and anti-inflammatory ...
• In vivo antiplasmodial and in vitro antioxidant properties of stem bark extracts of Haematostaphis barteri 

  Boampong, Johnson Nyarko; karikari, Akua Afryie; Ameyaw, Elvis Ofori (University of Cape Coast, 2015-02-03)

  Objective: To evaluate the antimalarial and antioxidant properties of stem bark extracts of Haematostaphis barteri (H. barteri). Methods: The prophylactic activity of the plant was performed by dosing mice with sulfad ...
• In vitro Cercaricidal Activity of Fractions and Isolated Compounds of Erythrophleum ivorense (Fabaceae) Root Bark against Schistosoma haematobium 

  Armah, Francis A.; Amoani, Benjamin; Henneh, Isaac T.; Dickson, Rita A.; Adokoh, Christian K.; Amponsah, Isaac Kingsley; Adu-Gyamfi, Cecilia; Acheampong, Desmond Omane (University of Cape Coast, 2019-02-15)

  ntroduction: Schistosoma haematobium is one of the species of Schistosoma responsible for schistosomiasis in humans, a major public health problem worldwide. Praziquantel, the most effective drug against all adult stages ...
• In vitro activity of Erythrophleum ivorense extract against the promastigote stage of cutaneous Leishmania parasite, a member of Leishmania (Mundinia) enriettii complex isolates from Ghana 

  Anning, Alberta Serwah; Kwakye-Nuako, Godwin; Ameyaw; Ameyaw, Elvis Ofori; Mosore, Mba-Tihssommah; Asare, Kwame Kumi (University of Cape Coast, 2019-09)

  Background. Cutaneous leishmaniasis causes physical disfigurement and impairment on affected individuals, however, little attention has been paid to it eradication. The situation of this neglected disease is complicated ...
• Investigation of a New Focus of Cutaneous Leishmaniasis in Ghana 

  Kwakye-Nuako, George (University of Cape Coast, 2016-02)

  Leishmaniasis is a disease of significant public health importance, which burdens a number of countries around the world, particularly in the tropics and subtropics. An outbreak of suspected cutaneous leishmaniasis (CL) ...
• Intracytoplasmic expression of IL-6 and IL-17A in circulating CD4+ T cells are strongly associated with and predict disease activity in rheumatoid arthritis: A case-control study in Ghana 

  Sakyi, Samuel Asamoah; Buckman, Tonnies Abeku; Antwi-Berko, Daniel; Yeboah-Mensah, Kwame; Dey, Dzifa; Owiredu, Eddie-Williams; Amoani, Benjamin; Mantey, Richard (University of Cape Coast, 2016)

  Background T cell cytokines play important roles in the development and progression of rheumatoid arthritis (RA). Loss of Th1/Th2 and Th17/Treg balance has been reported in several in ammatory autoimmune diseases. ...
• First isolation of a new species of Leishmania responsible for human cutaneous leishmaniasis in Ghana and classification in the Leishmania enriettii complex 

  Kwakye-Nuako, Godwin; Mosore, Mba-Tihssommah; Duplessis, Christopher; Bates, Michelle D.; Puplampu, Naiki; Mensah-Attipoe, Israel; Desewu, Kwame; Afegbe, Godwin; Asmah, Richard H.; Jamjoom, Manal B.; Ayeh-Kumi, Patrick F.; Boakye, Daniel A.; Bates, Paul A. (University of Cape Coast, 2015-06)

  An active case detection approach with PCR diagnosis was used in the Ho District of the Volta Region, Ghana that identified individuals with active cutaneous leishmaniasis. Three isolates were successfully cultured and ...
• Inhibition of Angiogenesis by Recombinant VEGF Receptor Fragments 

  Ahmadvand, Davoud; Rahbarizadeh, Fatemeh; Iri-Sofla, Farnoush Jafari; Namazi, Gholamreza; Khaleghi, Sepideh; Geramizadeh, Bita; Pasalar, Parvin; Karimi, Hosein; Bakhtiari, Seyed Hamid Aghaee (University of Cape Coast, 2010-07)

  Background: Blocking vascular endothelial growth factor receptor (VEGFR) is a successful approach for inhibiting vascular endothelial growth factor (VEGF) signaling. Small molecules impairing the interaction of VEGF ...
• Inducible nitric oxide synthase 2 promoter polymorphism and malaria disease severity in children in Southern Ghana 

  Dzodzomenyo, Mawuli; Ghansah, Anita; Ensaw, Nana; Dovie, Benjamin; Bimi, Langbong; Quansah, Reginald; Gyan, Ben A.; Gyakobo, Mawuli; Amoani, Benjamin (University of Cape Coast, 2018-08-17)

  Objective We assessed the association of mutant allele frequencies of nitric oxide synthase 2 (NOS2) gene at two SNPs (-954 and -1173) with malaria disease severity in children from a malaria endemic area in Southern ...
• AAV1/2-induced overexpression of A53T-α- synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson’s disease 

  Ip, Chi Wang; Klaus, Laura-Christin; Karikari, Akua A.; Visanji, Naomi P.; Brotchie, Jonathan M.; Lang, Anthony E.; Volkmann, Jens; Koprich, James B. (University of Cape Coast, 2017)

  α-Synuclein is a protein implicated in the etiopathogenesis of Parkinson’s disease (PD). AAV1/2-driven overexpression of human mutated A53T-α-synuclein in rat and monkey substantia nigra (SN) induces degeneration of ...
• Indigenous Medicinal Plants as Biofilm Inhibitors for the Mitigation of Antimicrobial Resistance 

  Ampofo, Elikplim Kwesi; Amponsah, Isaac Kingsley; Asante-Kwatia, Evelyn; Armah, Francis Ackah; Atchoglo, Philip Kobla; Mensah, Abraham Yeboah (University of Cape Coast, 2020-10-24)

  The majority of indigenes in the rural areas of Ghana use herbal medicines for their primary health care. In this study, an ethnobotanical survey was undertaken to document medicinal plants used by traditional healers in ...
• Increased Oxidative Stress and Inflammation Independent of Body Adiposity in Diabetic and Nondiabetic Controls in falciparum Malaria 

  Acquah, Samuel; Boampong, Johnson Nyarko; Eghan Jnr, Benjamin Ackon (University of Cape Coast, 2016-05-05)

  Information on the extent to which oxidative stress and inflammation occur in the presence of falciparum malaria and type 2 diabetes mellitus in the same individual is limited. This study sought to investigate the extent ...
• Impact of Iron Fortification on Anaemia and Iron Deficiency among Pre-school Children Living in Rural Ghana 

  Tchum, Samuel Kofi; Arthur, Fareed; Adu, Bright; Sakyi, Samuel Asamoah; Abubakar, Latifatu Alhassan; Atibilla, Dorcas; Amenga-Etego, Seeba; Oppong, Felix Boakye; Dzabeng, Francis; Amoani, Benjamin; Gyan, Thomas; Poku-Asante, Kwaku (University of Cape Coast, 2009-10-27)

  Micronutrient interventions, principally vitamin A and zinc supplementation for children, and fortification of foods with iron and iodine, are considered the most cost-effective global development efforts. Multiple ...
• Immunologic and virological response to ART among HIV infected individuals at a tertiary hospital in Ghana 

  Obiri -Yeboah, Dorcas; Pappoe, Faustina; Baidoo, Ibrahim; Arthur, Francis; Hayfron-Benjamin, Anna; Essien-Baidoo, Samuel; Kwakye-Nuako, Godwin; Ayisi Addo, Stephen (University of Cape Coast, 2018)

  Background: The need to study the outcome of Antiretroviral Therapy (ART) among Human Immunodeficiency Virus (HIV) infected individuals in Ghana, a sub-Saharan African country crucial in the era of the “Treat All” ...
• IgG Responses to the Plasmodium falciparum Antigen VAR2CSA in Colombia Are Restricted to Pregnancy and Are Not Induced by Exposure to Plasmodium vivax 

  Lopez-Perez, Mary; Larsen, Mads Delbo; Bayarri-Olmos, Rafael; Ampomah, Paulina; Stevenson, Liz; Arévalo-Herrera, Myriam; Herrera, Sócrates; Hviida, Lars (University of Cape Coast, 2018-05-18)

  Clinical immunity to malaria is associated with the acquisition of IgG specific for members of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family of clonally variant antigens on the surface of infected ...
• Identification of Sand Flies (Diptera: Psychodidae) Collected from Cutaneous Leishmaniasis Endemic Focus in the Ho Municipality, Ghana 

  Doe, Edna Dzifa; Kwakye-Nuako, Godwin; Addo, Seth Offei; Egyir-Yawson, Alexander (University of Cape Coast, 2020-09-04)

  Leishmaniasis, is a vector-borne disease transmitted to humans through the bite of infected female sand flies. Active and continuous monitoring of the sand fly is an important aspect of disease control. Thus, the correct ...
• Fibroblast Growth Factor-21 ameliorates hepatic encephalopathy by activating the STAT3-SOCS3 pathway to inhibit activated hepatic stellate cells 

  Opoku, Yeboah Kwaku; Liu, Zhihang; Afrifa, Justice; Kumi, Asare Kwame; Liu, Han; Ghartey-Kwansah, George; Koranteng, Harriet; Jiang, Xinghao; Ren, Guiping; Li, Deshan (University of Cape Coast, 2020-05-04)

  Neurological dysfunction, one of the consequences of acute liver failure (ALF), and also referred to as hepatic encephalopathy (HE), contributes to mortality posing challenges for clinical management. FGF21 has been implicated ...
• Hypotensive effect of an aqueous extract of Heliotropium indicum Linn (Boraginaceae) 

  Koffuor, George Asumeng; Boye, Alex; Ameyaw, Elvis Ofori; Amoateng, Patrick; Abiatey, Alfred K. (University of Cape Coast, 2012-04-02)

  Heliotropium indicum Linn (Boraginaceae) has been used widely in the treatment of hypertension in Ghana. This study therefore was aimed at investigating the effects of an aqueous extract of H. indicum Linn on the heart ...
• Housing Surroundings and Self-reported Cases of Malaria in two Communities in Central Region of Ghana 

  Ampomah, Paulina; Afriyie, James (University of Cape Coast, 2017-12)

  Malaria remains a major health problem in Ghana. Mosquito breeding sites play significant role in malaria infection and transmission, but studies in this area are scanty in Ghana. This study assesses the association between ...
• Household Fuel And Garbage Combustion, Street Vending Activities And Adverse Pregnancy Outcomes 

  Amegah, Adeladza Kofi (University of Cape Coast, 2014)

  Air pollution is a major concern in urban areas of developing countries as a result of industrial expansion and increased vehicular ownership, and in most households due to solid fuel use and garbage burning at home. ...

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