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A study of the geographic distribution and associated risk factors of leg ulcers within an international cohort of sickle cell disease patients: the CASiRe group analysis

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dc.contributor.author Antwi-Boasiako, Charles
dc.contributor.author Andemariam, Biree
dc.contributor.author Colombatti, Raffaella
dc.contributor.author Vicky Asare, Eugenia
dc.date.accessioned 2021-03-22T12:15:17Z
dc.date.available 2021-03-22T12:15:17Z
dc.date.issued 2020-04
dc.identifier.uri http://hdl.handle.net/123456789/5085
dc.description.abstract Vasculopathy is a hallmark of sickle cell disease ultimately resulting in chronic end organ damage. Leg ulcer is one of its sequelae, occurring in ~ 5–10% of adult sickle cell patients. The majority of leg ulcer publications to date have emanated from single center cohort studies. As such, there are limited studies on the geographic distribution of leg ulcers and associated risk factors worldwide. The Consortium for the Advancement of Sickle Cell Research (CASiRe) was formed to improve the understanding of the different phenotypes of sickle cell disease patients living in different geographic locations around the world (USA, UK, Italy, Ghana). This cross-sectional cohort sub-study of 659 sickle cell patients aimed to determine the geographic distribution and risk factors associated with leg ulcers. The prevalence of leg ulcers was 10.3%and was associated with older age, SS genotype, male gender, and Ghanaian origin. In fact, the highest prevalence (18.6%) was observed in Ghana. Albuminuria, proteinuria, increased markers of hemolysis (lower hemoglobin, higher total bilirubin), lower oxygen saturation, and lower body en_US
dc.language.iso en en_US
dc.subject ulcers en_US
dc.subject sickle cell en_US
dc.title A study of the geographic distribution and associated risk factors of leg ulcers within an international cohort of sickle cell disease patients: the CASiRe group analysis en_US
dc.type Article en_US


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