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Hematological parameters in Ghanaian sickle cell disease patients

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dc.contributor.author Antwi-Boasiako, Paul
dc.contributor.author Ekem, Ivy
dc.contributor.author Abdul-Rahman, Mubarak
dc.date.accessioned 2021-03-22T13:55:46Z
dc.date.available 2021-03-22T13:55:46Z
dc.date.issued 2018-04
dc.identifier.uri http://hdl.handle.net/123456789/5092
dc.description.abstract Background: Effective treatment and management of sickle cell disease (SCD) has been a challenge in Africa over the years. Hematological parameters are very useful profiles in the effective management of the disease. However, there is scarcity of studies on the hematological parameters of SCD in Ghana. This study aimed at determining hematological parameters among SCD patients with vaso-occlusion, those in the steady state as well as healthy controls at a teaching hospital in Ghana. Methodology: This was a cross-sectional study involving a total of 628 subjects, including 148 HbAA controls, 208 HbSS patients in steady state, 82 HbSC patients in steady state, 156 HbSS patients in vaso-occlusive crises (VOC), and 34 HbSC patients in VOC. Venous blood sample was collected from all study participants. A full blood count was done within 2 hours of collection, and hemoglobin (Hb) concentration, packed cell volume, red blood cell (RBC) concentration, mean corpuscular Hb, mean cell volume, mean corpuscular Hb concentration, and white blood cells (WBC) and platelet (PLT) counts were recorded. Results: WBC and PLT counts were significantly higher in both female and male patients with SCD, compared with their healthy counterparts (P<0.05). The level of WBC was, however, significantly higher in patients with HbSS VOC among the SCD patients (P<0.001). Levels of Hb, RBC, and hematocrit were significantly higher in the controls (P<0.001). There was no significant difference in mean cell Hb among male patients with SCD (P=0.274) and female patients with SCD (P=0.5410). Conclusion: The SCD patients had lower Hb and RBC than the controls; however, higher PLT and WBC are noted in various status of SCD, possibly reflecting spleen effect in these patients. Further studies are needed to confirm these findings en_US
dc.language.iso en en_US
dc.subject Hematological en_US
dc.subject sickle cell disease, en_US
dc.subject full blood count en_US
dc.subject anemia en_US
dc.title Hematological parameters in Ghanaian sickle cell disease patients en_US
dc.type Article en_US


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