Biochemicophysiological mechanisms underlying signs and symptoms associated with diabetes mellitus

Abstract

Diabetes mellitus is a disorder, which has become a major health burden all over the world. This metabolic disorder currently has no cure A search of database sites such as Medline, Elsevier, Springer, Science Direct, PubMed, Google Scholar, Web of science, as well as other sources of literature available across public libraries was conducted to obtain information related to the topic. This review has presented a discussion on the biochemical and physiological mechanisms underlying the associated signs and symptoms of diabetes mellitus by relating it to the role of insulin in glucose uptake in cells and fuel metabolism. This exposé is anticipated to enlighten researchers on specific management targets, which may warrant future research into developing pharmacological and non-pharmacological therapies as a means of managing diabetes mellitus, its associated signs and symptoms and ultimately chronic complications. An understanding of how these signs and symptoms develop, early recognition of it by patients and diagnosis of condition by healthcare professionals coupled with early management can prevent or delay the onset of chronic complications and ultimately reduce mortality and morbidity rate in the general population