Abstract:
Heavy metal accumulation in the food chain is an issue of global concern because it eventually leads to toxic effects on humans through the water we drink, contaminated soils, crops, and animals. Reports of toxic ant levels in environmental media (air, water, and soil) and biotin Ghana were sought in SCOPUS, PubMed, MEDLINE, and EMBASE. Of 1004 bibliographic records identified, 54 studies were included in evidence synthesis. A disproportionately large number of papers (about80%) focused exclusively on environmental media. Papers focusing on bio monitoring and human health were relatively few. Studies reported a high degree of spatial variability for the concentrations of 8 metals in groundwater. Generally, heavy metal concentrations in soil reported by the studies reviewed were higher than metal concentrations in river in sediments. Urine and hair were the most common biological markers of heavy metal exposure used by the studies reviewed unlike nails, which were sparingly used. By and large, published results on the levels of heavy metals in goldmine and non-mine workers yielded contradictory results. Mostly, concentrations of heavy metals reported by the studies reviewed for nails were higher than for hair. A high degree of variability in the heavy metal concentrations in human subjects in the studies reviewed is likely due to heterogeneity in physiological states, excretion profiles, and body burdens of individuals. These, in turn, may be a product of genetic polymorphisms influencing detoxification efficiency
