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Antibacterial and toxicological evaluation of the ethanol leaf extract of Anthonotha macrophylla

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dc.contributor.author Essiet, Grace Akanimo
dc.contributor.author Anwankwo, Monday Udofa
dc.contributor.author Akuodor2, Godwin Christian
dc.contributor.author Ajoku, Gloria Ahunna
dc.contributor.author Aja, Daniel Ogbonna John
dc.date.accessioned 2021-04-14T11:38:44Z
dc.date.available 2021-04-14T11:38:44Z
dc.date.issued 2019-03
dc.identifier.uri http://hdl.handle.net/123456789/5337
dc.description.abstract Introduction: The leaves of Anthonotha macrophylla which are widely used in folkloric medicine in Africa were evaluated for antibacterial activity and its toxicological profile. Methods: Antibacterial activities of the leaves against clinical strains of Staphylococcus aureus, Escherichia coli, Salmonella typhi, Klebsiella pneumonia, Streptococcus pyogenes and Bacillus subtilis were compared with cefoxitin. Toxicological profiles were determined following the administration of 100, 200 and 400 mg/kg of the leaf extract and distilled water, as control, to male Albino rats for 28 days. Biochemical and hematological indices and body weights were determined and the vital organs were examined. Results: The ethanol leaf extract of A. macrophylla demonstrated antibacterial activity against the pathogenic bacteria tested. Toxicological investigation of the leaf extract showed no significant alterations in hematological and biochemical indices, and the vital organs as well. The LD50 in rats was more than 5000 mg/kg. Conclusion: Findings suggest that the ethanol leaf extract of A. macrophylla possess good antimicrobial activity which supports the traditional use of this plant across Africa. The plant is also considered safe following oral exposure after 28 days. en_US
dc.language.iso en en_US
dc.subject Anthonotha macrophylla en_US
dc.subject Leaf extract en_US
dc.subject Antibacterial activity en_US
dc.subject Toxicological assessment en_US
dc.title Antibacterial and toxicological evaluation of the ethanol leaf extract of Anthonotha macrophylla en_US
dc.type Article en_US


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