A novel inhibitor of human telomerase derived from 10h-indolo[3,2-b]quinoline

dc.contributor.author	Caprio, Vittorio
dc.contributor.author	Guyen, Berengere
dc.contributor.author	Opoku-Boahen, Yaw
dc.contributor.author	Mann, John
dc.contributor.author	Gowan, Sharon M.
dc.contributor.author	Kelland, Lloyd M.
dc.contributor.author	Readd, Martin A.
dc.contributor.author	Neidle, Stephen
dc.date.accessioned	2021-07-07T11:39:41Z
dc.date.available	2021-07-07T11:39:41Z
dc.date.issued	2000
dc.identifier.issn	23105496
dc.identifier.uri	http://hdl.handle.net/123456789/5606
dc.description	4p:, ill.	en_US
dc.description.abstract	The bis-dimethylaminoethyl derivative of quindoline (10H-indolo[3,2-b]quinoline), an alkaloid from the West African shrub Cryptolepis sanguinolenta, has been synthesised. This has been shown to have modest cytotoxicity, as well as inhibitory activity against the telomerase enzyme. It is hypothesized that the latter activity is due to stabilization of an intermediate guaninquadruplex complex, in accordance with computer modelling	en_US
dc.language.iso	en	en_US
dc.publisher	University of Cape Coast	en_US
dc.title	A novel inhibitor of human telomerase derived from 10h-indolo[3,2-b]quinoline	en_US
dc.type	Article	en_US