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Anti-inflammatory and Antioxidant Activities of Canthinone Alkaloids from Anthostema aubryanum (Baill)

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dc.contributor.author Fynn, Patrick Malcolm
dc.contributor.author Opoku-Boahen, Yaw
dc.contributor.author Adukpo, Genevieve Etornam
dc.contributor.author Armah, Francis Ackah
dc.date.accessioned 2021-07-12T11:23:34Z
dc.date.available 2021-07-12T11:23:34Z
dc.date.issued 2016
dc.identifier.issn 23105496
dc.identifier.uri http://hdl.handle.net/123456789/5633
dc.description 13p:, ill. en_US
dc.description.abstract The stem and root bark of Anthostema aubryanum (Baill, family, Euphorbiaceae) are extensively used in African ethnomedicine for treating and managing a number of disease conditions which include inflammation, pain, wounds, boil, dyspepsia and a variety of other disease conditions. Although the chemistry and pharmacology of many phyto constituents isolated from the family are fairly established, the plant has not yet been investigated. In the present study, an alkaloidal extract of the root bark was demonstrated to display a time- and dose (30-300 mg/Kg p.o.)-dependent anti-inflammatory effect in rats (ED50=13.84±0.011) compared to diclofenac (ED50=1.994±0.002). Comprehensive chromatographic and spectroscopic analyses have led to the isolation and characterization of two major anti-inflammatory and antioxidant alkaloids as 5-methoxycanthin-6-one and canthin-6-one. The dose (10-100 mg/Kg p.o.)-dependent anti-inflammatory effects of the 5-methoxycanthin-6-one (ED50=60.84±0.010) and canthin 6-one (ED50=96.64±0.012) were either comparable or significant as the positive control, diclofenac. The radical scavenging activity of the alkaloidal extract (IC50=23.12±0.010), 5-methoxycanthin-6-one (IC50=27.62±0.090) and canthin-6-one (IC50=33.60±0.011) was also significantly comparable to Vitamin E (IC50=8.605±0.002) used as positive control. Canthinone alkaloids are well-known constituents of the Simaroubaceae and Rutaceae and display a wide range of biological activities. However, they are being reported as constituents of the Euphorbiaceae here for the first time en_US
dc.language.iso en en_US
dc.publisher University of Cape Coast en_US
dc.subject Anthostema aubryanum en_US
dc.subject Euphorbiaceae en_US
dc.subject Free radicals en_US
dc.subject Anti-inflammatory en_US
dc.subject Antioxidant en_US
dc.subject 5-methoxycanthin-6-one en_US
dc.subject Canthin-6-one en_US
dc.title Anti-inflammatory and Antioxidant Activities of Canthinone Alkaloids from Anthostema aubryanum (Baill) en_US
dc.type Animation en_US
dc.type Article en_US


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