Synthesis of an enantiomerically pure building block for the synthesis of hydroporphyrins

dc.contributor.author	Adukpo, Genevieve Etornam
dc.contributor.author	Borrmann, Tobias
dc.contributor.author	Manski, René
dc.contributor.author	Díaz, Rosa I. Sáez
dc.contributor.author	Stohrer, Wolf-Dieter
dc.contributor.author	Montforts, Franz-Peter
dc.date.accessioned	2021-08-16T09:43:20Z
dc.date.available	2021-08-16T09:43:20Z
dc.date.issued	2007
dc.identifier.issn	23105496
dc.identifier.uri	http://hdl.handle.net/123456789/5859
dc.description	9p:, ill.	en_US
dc.description.abstract	The enantiomerically pure pyrrolidine diester 4 is a useful building block for the synthesis of chiral hydroporphyrin compounds. Treatment of optically active aromatic amines with bislactone 5 gave pairs of N-alkylated lactam-lactone diastereomers 6 and 8. These diastereomers were separated by MPL chromatography and in the case of 8 they could be debenzylated to yield the enantiomerically pure lactam-lactone 7 and its enantiomer. The (–)-lactam-lactone enantiomer 7 was further transformed into building block 4	en_US
dc.language.iso	en	en_US
dc.publisher	University of Cape Coast	en_US
dc.subject	Hydroporphyrins	en_US
dc.subject	Nitrogen heterocycles	en_US
dc.subject	Chiral resolution	en_US
dc.subject	Circular dichroism	en_US
dc.title	Synthesis of an enantiomerically pure building block for the synthesis of hydroporphyrins	en_US
dc.type	Article	en_US