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A 56-Day Oral Toxicity Study of the queous Extract of Rapanea melanophloeos (L.) Mez in Rats

Show simple item record Amenya, Hesbon Z. Mbaria, James M. Thaiyah, Andrew G. Thoithi, Grace N. Gathumbi, Peter K. 2022-02-16T11:35:46Z 2022-02-16T11:35:46Z 2016
dc.identifier.issn 23105496
dc.description 11p:, ill. en_US
dc.description.abstract Rapanea melanophloeos is a tropical tree that is extensively utilized in African traditional medicine to treat helminthiases, tuberculosis, and heart-water. As with many other medicinal plants, there is insufficient information regarding the safety of therapeutic R. melanophloeos extracts. An aqueous extract of R. melanophloeos stem bark was administered to Sprague Dawley rats at doses of 100 mg/kg, 300 mg/kg, and 1000 mg/kg for 56 days to characterize its potential toxicity after prolonged dosing. Blood samples were obtained fortnightly for serum chemistry and hematology, while organs were collected at the end of the study. The extract caused an increase in organ weight indices of the kidneys and testis at 300 mg/kg and 1000 mg/kg. Hematological and biochemical examination revealed a drop in leukocyte counts and the hematocrit at 1000 mg/kg dose level, while there was a general but nondose-related elevation in alkaline phosphatase activity. There were time-associated ariations in the hematological and clinical chemistry parameters at days 28, 42, and 56 in all dose levels, but most alues remained within physiological limits. No pathological lesions were evident at histopathology after treatment with the extract. Our data shows that the aqueous extract of R. melanophloeos is not likely to be toxic at the doses tested and provides support to its medicinal use en_US
dc.language.iso en en_US
dc.publisher University of Cape Coast en_US
dc.title A 56-Day Oral Toxicity Study of the queous Extract of Rapanea melanophloeos (L.) Mez in Rats en_US
dc.type Article en_US

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