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Effects of Chronic Hepatitis B Infection on Pregnancy and Birth Outcomes in Ghana

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dc.contributor.author Siakwa, Mate
dc.contributor.author Kpikpitse, Dzigbodi
dc.contributor.author Ankobil, Amandus
dc.contributor.author Mupepi, Sylvia
dc.contributor.author John, Mildred E.
dc.contributor.author Doe, Patience F.
dc.contributor.author Ebu, Nancy I.
dc.contributor.author Dare, Shadrach
dc.contributor.author Hansen-Owoo, E.
dc.date.accessioned 2022-04-08T14:38:51Z
dc.date.available 2022-04-08T14:38:51Z
dc.date.issued 2014-09
dc.identifier.issn 23105496
dc.identifier.uri http://hdl.handle.net/123456789/8163
dc.description 13p:, ill. en_US
dc.description.abstract Ghana is a known endemic area for hepatitis B virus (HBV) infections, yet the consequences of HBV infection on pregnancy outcomes are unknown. This prospective cohort study was thus conducted among 512 pregnant women attending antenatal clinic in the Cape Coast Teaching Hospital, Ghana, between January, 2011 and December, 2013 to determine the effects of hepatitis B during pregnancy on birth outcomes in Ghana. The HBsAg status of all pregnant women was determined by the latex agglutination test while a researcher administered semi-structured checklist was used to collect demographic/obstetric/medical data of respondents. We obtained 262 HBsAg positive and 250 HBsAg negative women most of whom were aged 20-29 (40%), classified themselves as low income earners (50%), and had attained primary education (42%). Logistic regression analysis showed that pregnant women who had chronic hepatitis B were more likely to develop PROM (p=0.008) and foul smelling liquor (p=0.024) at delivery. Moreover, neonatal consequences for chronic hepatitis B were; preterm babies (p=0.002), underweight (p<0.001), Apgar score lower than 7 (p<0.001), asphyxia at birth (p=0.006) and still birth (p=0.04). We conclude that babies born to mothers with positive HBsAg status have a higher risk for vertical transmission as well as adverse neonatal consequences. en_US
dc.language.iso en en_US
dc.publisher University of Cape Coast en_US
dc.subject Hepatitis B en_US
dc.subject Neonatal outcome en_US
dc.subject Pregnancy outcome en_US
dc.subject Ghana en_US
dc.title Effects of Chronic Hepatitis B Infection on Pregnancy and Birth Outcomes in Ghana en_US
dc.type Article en_US


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