Abstract:
To study the time course (onset, time and duration of maximal cycloplegia, and the full duration) of cycloplegic action
of 1% Cyclopentolate – 1% Tropicamide.
Methods: Seventy-seven students, aged 15-24 years were purposively sampled from the University of Cape Coast and Cape
Coast Technical Institute. Subjective near addition (ADD) determination and pupil diameter measurement before and after a
drop of the test agent (1% Cyclopentolate – 1% Tropicamide combination in the right eye) and the control (1% Cyclopentolate
in the left eye) were performed. Measurements of subjective near ADD and pupil diameter were made after the initial reading at
5 minutes interval for the first hour and every 30 minutes for the next 7 hours for each participant. Time of onset, time of peak
cycloplegia, duration of peak cycloplegia and duration of total cycloplegic effect was indirectly determined.
Results: 1% Cyclopentolate – 1% Tropicamide combination had rapid onset of cycloplegia (5-10 minutes), shorter time of
maximal cycloplegia (55 versus 90 minutes), and recovery (7 versus ≥ 8hours) in the majority (79.2%) of subjects.
Conclusion: Cyclopentolate –Tropicamide combination was comparable to Cyclopentolate in depth of cycloplegia produced,
and clinically superior to 1% Cyclopentolate in rapidity of cycloplegic onset, time of maximal cycloplegia and recovery from
cycloplegia.
