Browsing UCC RESEARCH OUTPUT by Author "Maroyi, Alfred"

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In Vitro Reversible and Time-Dependent CYP450 Inhibition Profiles of Medicinal Herbal Plant Extracts Newbouldia laevis and Cassia abbreviata: Implications for Herb-Drug Interactions

Thomford, Nicholas Ekow; Dzobo, Kevin; Chopera, Denis; Wonkam, Ambroise; Maroyi, Alfred; Blackhurst, Dee; Dandara, Collet (Molecules, 2016-07-07)

This study evaluated the effects of Newbouldia laevis and Cassia abbreviata extracts on CYP450 enzyme activity. Recombinant CYP450 enzyme and fluorogenic substrates were used for evaluating inhibition, allowing the ...
Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery

Thomford, Nicholas Ekow; Senthebane, Dimakatso Alice; Rowe, Arielle; Munro, Daniella; Seele, Palesa; Maroyi, Alfred (International Journal of Molecular Sciences, 2018-05-25)

The therapeutic properties of plants have been recognised since time immemorial. Many pathological conditions have been treated using plant-derived medicines. These medicines are used as concoctions or concentrated plant ...

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