University of Cape Coast Institutional Repository

Browsing UCC RESEARCH OUTPUT by Author "Senthebane, Dimakatso Alice"

Browsing UCC RESEARCH OUTPUT by Author "Senthebane, Dimakatso Alice"

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  • Advances in Therapeutic Targeting of Cancer Stem Cells within the Tumor Microenvironment: An updated Review 
    Senthebane, Dimakatso Alice; Ganz, Chelene; Thomford, Nicholas Ekow; Dzobo, Kevin (Cells, 2020)
    Abstract: Despite great strides being achieved in improving cancer patients’ outcomes through better therapies and combinatorial treatment, several hurdles still remain due to therapy resistance, cancer recurrence and ...
  • Chemoresistance to Cancer Treatment: Benzo-α-Pyrene as Friend or Foe? 
    Dzobo, Kevin; Hassen, Naseeha; Senthebane, Dimakatso Alice; Thomford, Nicholas Ekow; Rowe, Arielle; Shipanga, Hendrina; Wonkam, Ambroise; Parker, M. Iqbal; Mowla, Shaheen; Dandara, Collet (Molecules, 2018-04-17)
    Abstract: Background: Environmental pollution such as exposure to pro-carcinogens including benzo-α-pyrene is becoming a major problem globally. Moreover, the effects of benzo-α-pyrene (BaP) on drug pharmacokinetics, ...
  • Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery 
    Thomford, Nicholas Ekow; Senthebane, Dimakatso Alice; Rowe, Arielle; Munro, Daniella; Seele, Palesa; Maroyi, Alfred (International Journal of Molecular Sciences, 2018-05-25)
    The therapeutic properties of plants have been recognised since time immemorial. Many pathological conditions have been treated using plant-derived medicines. These medicines are used as concoctions or concentrated plant ...
  • Not Everyone Fits the Mold: Intratumor and Intertumor Heterogeneity and Innovative Cancer Drug Design and Development 
    Dzobo, Kevin; Senthebane, Dimakatso Alice; Thomford, Nicholas Ekow; Rowe, Arielle; Dandara, Collet; Parker, M. Iqbal (OMICS A Journal of Integrative Biology, 2018)
    Disruptive innovations in medicine are game-changing in nature and bring about radical shifts in the way we un- derstand human diseases, their treatment, and/or prevention. Yet, disruptive innovations in cancer drug design ...
  • The Role of Tumor Microenvironment in Chemoresistance: To Survive, Keep Your Enemies Closer 
    Senthebane, Dimakatso Alice; Rowe, Arielle; Thomford, Nicholas Ekow; Shipanga, Hendrina; Munro, Daniella; Al Mazeedi, Mohammad A. M.; Almazyadi, Hashim A. M.; Kallmeyer, Karlien; Dandara, Collet; Pepper, Michael S.; Parker, M. Iqbal; Dzobo, Kevin (International Journal of Molecular Sciences, 2017-07-21)
    Chemoresistance is a leading cause of morbidity and mortality in cancer and it continues to be a challenge in cancer treatment. Chemoresistance is influenced by genetic and epigenetic alterations which affect drug uptake, ...
  • The significance of Cancer stem cell markers’ gene expression and Relevance for Survival Outcomes 
    Dzobo, Kevin; Senthebane, Dimakatso Alice; Ganz, Chelene; Thomford, Nicholas Ekow (School of Clinical Medicine, Wits Medical School, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa., 2020)
    Solid tumors display complex biology and most therapies including chemotherapy cannot prevent therapy resistance and relapse. Most therapeutics target cancer cells, but recent data suggest the presence of cancer stem ...

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