Browsing UCC RESEARCH OUTPUT by Author "Whittle, Hilton"

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Comparison of Cytotoxic activity and Interferon-g secretion by Natural Killer Cells in HIV-1 and HIV-2 infected individuals

Nuvor, Samuel Victor; Rowland-jones, Sarah; Whittle, Hilton; Jaye, Assan (Retrovirology, 2010)

Background The role of NK cells in slowing disease progression in HIV-2 infected individuals compare to HIV-1 infected individuals. Methods In this study peripheral blood mononuclear cells were obtained from 30 HIV-1 ...
Greater Expansion of IFN-− CD4+ NKT Cells in HIV-1 Compared with HIV-2-Infected Subjects with Preserved CD4+ T Cell Counts

Nuvor, Samuel V.; Whittle, Hilton; Rowland-Jones, Sarah; Jaye, Assan (World Journal of AIDS, 2012)

Context: Human Natural Killer T cells are T lymphocytes that express an invariant  T cells receptors and NK cells receptors. They regulate innate and adaptive immune response but are susceptible to HIV-1 infection. ...
Natural Killer Cell Function Is Well Preserved in Asymptomatic Human Immunodeficiency Virus Type 2 (HIV-2) Infection but Similar to That of HIV-1 Infection When CD4 T-Cell Counts Fall

Nuvor, Samuel Victor; Sande, Marianne van der; Rowland-Jones, Sarah; Whittle, Hilton; Jaye, Assan (JOURNAL OF VIROLOGY, 2006)

Natural killer (NK) cells are potent effectors of natural immunity and their activity prevents human immunodeficiency virus type 1 (HIV-1) viral entry and viral replication. We sought to determine whether NK immune responses ...

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