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Effects of Hydroalcoholic leaf Extract of Ficus Exasperata Vahl (Moraceae) In Carrageenan! Kaolin-Induced Acute and Chronic Musculoskeletal Pain in Rats

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dc.contributor.author Boakye-Gyasi, Eric
dc.contributor.author Abotsi, Wonder K. M.
dc.contributor.author Biney, Robert P.
dc.contributor.author Amevaw, Elvis O.
dc.contributor.author Woode, Eric
dc.date.accessioned 2023-10-20T19:35:05Z
dc.date.available 2023-10-20T19:35:05Z
dc.date.issued 2014
dc.identifier.uri http://hdl.handle.net/123456789/9797
dc.description.abstract Background: Leaf extracts of Ficus exasperata has been used traditionally in Ghana for the management of sprains, sore eyes, rheumatism and arthritis. Objective: This study evaluates the scientific basis for the use of Ficus exasperata leaves in the management of acute and chronic musculoskeletal pain Methods: The carrageenan-kaolin-induced hyperalgesia model was used to assess acute and chronic musculoskeletal pain using the Randall-Sellito and the grip strength tests using morphine as a reference drug. Results: F. exasperata extract (30-300 mg kg-i) significantly and dose-dependently decreased acute skeletal pain as well as chronic skeletal hyperalgesia in the ipsilateral and contralateral paws with maximum possible anti-hyperalgesia effects being achieved at the highest dose. Furthermore, it completely reversed both acute and chronic muscle hyperalgesia in a significant and dosedependent manner. Conclusion: These findings thus support the usefulness of Ficus exasperata leaf extracts in the management of musculoskeletal pain. en_US
dc.language.iso en en_US
dc.publisher West African Journal of Pharmacy en_US
dc.subject Musculoskeletal pain en_US
dc.subject grip strength en_US
dc.subject hyperalgesia en_US
dc.subject morphine en_US
dc.subject carrageenan/kaolin en_US
dc.title Effects of Hydroalcoholic leaf Extract of Ficus Exasperata Vahl (Moraceae) In Carrageenan! Kaolin-Induced Acute and Chronic Musculoskeletal Pain in Rats en_US
dc.type Article en_US


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