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Ziziphus abyssinica hydro-ethanolic root bark extract attenuates acute inflammation possibly through membrane stabilization and inhibition of protein denaturation and neutrophil degranulation

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dc.contributor.author Henneh, Isaac T.
dc.contributor.author Ameyaw, Elvis O.
dc.contributor.author Biney, Robert P.
dc.contributor.author Armah, Francis A.
dc.contributor.author Obese, Ernest
dc.contributor.author Konjah, Daniels
dc.contributor.author Eric, Teye Otumi
dc.date.accessioned 2023-10-23T13:12:02Z
dc.date.available 2023-10-23T13:12:02Z
dc.date.issued 2018
dc.identifier.uri http://hdl.handle.net/123456789/9862
dc.description.abstract Background: Despite the widespread use of Ziziphus abyssinica (ZAE) roots and claims of its efficacy against diverse inflammatory conditions in traditional medicine, there is paucity of information on the scientific basis for its folkloric use. Objectives: The current study evaluated the anti-inflammatory property of the root bark extract of ZAE and its possible mechanism(s) of action in in vivo and in vitro experimental models. Methods: Anti-inflammatory activity of ZAE was assessed in vitro using heat and hypotonic solution – induced haemolysis as well as egg albumin (EA) and bovine serum albumin (BSA) denaturation assays. Carrageenan and formalin-induced paw oedema and carrageenan-induced peritonitis in rats were used to evaluate the anti-inflammatory property of the extract in vivo. Results: ZAE (100, 300 and 1000 µg/mL) significantly inhibited heat and hypotonic solution-induced haemolysis as well as EA and BSA-induced denaturation. ZAE (300 mg/kg, p.o.) similar to diclofenac (10 mg/kg, p.o.), significantly (P<0.05) reduced paw oedema by 40.77±6.82 and 54.81 ± 3.74% respectively in carrageenan-induced paw oedema test. The percentage inhibitions produced by ZAE (30, 100 and 300 mg/kg, p.o.) were 3.31±22.12, 49.89±2.98 and 76.98±0.50 % respectively compared to 80.51±0.53 % produced by diclofenac (10 mg/kg, p.o.) in the formalin-induced paw oedema test. Massive recruitment of leukocytes (mainly neutrophils) into the peritoneal cavity of the rats by carrageenan was significantly (P<0.01) reduced by ZAE (30, 100 and 300 mg/kg p.o.) and dexamethasone (5 mg/kg, p.o.). Conclusions: The inhibitory effect of ZAE against acute inflammation in this study provides scientific basis for its use in folk medicine and reveals its potential as a source of novel anti-inflammatory agent. en_US
dc.language.iso en en_US
dc.publisher West African Journal of Pharmacy en_US
dc.subject Ziziphus abyssinica en_US
dc.subject Carrageenan-induced peritonitis en_US
dc.subject Formalin-induced paw oedema en_US
dc.subject acute inflammation en_US
dc.subject in vitro en_US
dc.subject anti-inflammatory property en_US
dc.title Ziziphus abyssinica hydro-ethanolic root bark extract attenuates acute inflammation possibly through membrane stabilization and inhibition of protein denaturation and neutrophil degranulation en_US
dc.type Article en_US


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