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Department of Biomedical & Forensic Sciences: Recent submissions

Now showing items 61-80 of 94

Flavonoid-rich extract of Dissotis Rotundifolia whole plant protects against ethanol-induced gastric mucosal damage

Dinortey, Michael Buenor; Ansah, Charles; Aboagye, Benjamin; Sarfo, Justice Kwabena; Martey, Orleans; Nyarko, Alexander Kwadwo (University of Cape Coast, 2020-04-01)

Dissotis rotundifolia is a plant in the family Melastomataceae. 'e methanolic extract of the whole plant is reported to be rich in C-glycosylfavones such as itexin and orientin. Tough there are several reports on the ethno ...
Field-caught permethrin-resistant anopheles ambiae overexpress cyp6p3, a p450 that metabolises Pyrethroids

Muller, Pie; Warr, Emma; Stevenson, Bradley J.; Pignatelli, Patricia M.; Morgan, John C.; Steven, Andrew; Yawson, Alexander E.; Mitchell, Sara N.; Mitchell, Sara N.; Ranson, Hilary; Hemingway, Janet; Donnelly, Martin J. (University of Cape Coast, 2008-11-28)

Insects exposed to pesticides undergo strong natural selection and have developed various adaptive mechanisms to survive. Resistance to pyrethroid insecticides in the malaria vector Anopheles gambiae is receiving increasing ...
Fibroblast transdifferentiation promotes conversion of M1 macrophages and replenishment of cardiac resident macrophages following cardiac injury in mice

Lu, Hongxiang; Chen, Rong; Barnie, Prince Amoah; Tian, Yu; Zhang, Shiqing; Xu, Huaxi; Chakrabarti, Subrata; Su, Zhaoliang (University of Cape Coast, 2020)

Resident cardiac macrophages play important roles in homeostasis, maintenance of cardiac function, and tissue repair. After cardiac injury, monocytes infiltrate the tissue, undergo phenotypic and functional changes, and ...
Feeding frequency and survival of Anopheles ambiae in a rice-growing area in Ghana

C h a r l w o o d, J. D.; T o m a s, E. V.; E g y i r - Y a w s o n, A.; K a m p a n g o, A. A.; P i t t s, R. J. (University of Cape Coast, 2011)

Mortality rates, determined by dissection, of predominantly M form female Anopheles gambiae (Diptera: Culicidae) were estimated. Mosquitoes were collected in tent traps and light traps in an irrigation project village in ...
Factors affecting birth weight in Cape Coast, Ghana

Prah, James; Ameyaw, Elvis O.; Afoakwah, Richmond; Kudom, Andreas (University of Cape Coast, 2016)

Background: This study aimed at determining the incidence of low birth weight among live births and maternal anaemia and to investigate the association between some maternal factors and birth weight. Methods: This was a ...
Exogenous high-mobility group box 1 inhibits apoptosis and promotes the proliferation of Lewis cells via rage/tlr4-dependent signal pathways

Xu, X.; Zhu, H.; Wang, T.; Sun, Y.; Ni, P.; Liu, Y.; Tian, S.; Barnie, P. Amoah; Shen§, H.; Xu, W.; Xu, H.; Su, Z. (University of Cape Coast, 2013)

Upregulated high-mobility group box 1 (HMGB1) has been found in many diseases. Nevertheless, the function of HMGB1 on modulating the proliferation of lung cancer cells (Lewis cells) and inhibiting apoptosis is poorly ...
. Evaluating 18s-rRNA LAMP and selective whole genome amplifcation (sWGA) assay in detecting asymptomatic Plasmodium falciparum infections in blood donors

Aninagyei, Enoch; Smith‑Graham, Stella; Boye, Alex; Egyir‑Yawson, Alexander; Acheampong, Desmond Omane (University of Cape Coast, 2019)

Background: Undesirable consequences of donor Plasmodium falciparum parasitaemia on stored donor blood have been reported. Therefore, it is imperative that all prospective blood donors are screened for P. falciparum ...
Ethanolic root extract of jatropha curcas l. relieves muscle pain in rats

Ameyaw ., E. O; Edem, Kukuia K. K.; Boampong, J. N.; Thomford ., A. K; Anane, R. F.; Tabiri, I.; Yaw., A. I (University of Cape Coast, 2014)

The roots of Jatropha curcas are used traditionally to treat pain. The present study evaluated the analgesic property of ethanolic extract of Jatropha curcas (JAT) in acute and chronic muscle pain models. Acute muscle ...
Ethnopharmacological evaluation of schistosomicidal and cercaricidal activities of some selected medicinal plants from Ghana

Acheampong, Desmond Omane; Owusu-Adzorah, Ninette; Armah, Francis Ackah; Aninagyei, Enoch; Asiamah, Ernest Amponsah; Thomford, Ama Kyeraa; Anyan, William Kofi (University of Cape Coast, 2020)

The adulticidal and cercaricidal activities of five Ghanaian medicinal plants, namely, Phyllanthus amarus, Vernonia amygdalina, Azadirachta indica, Morinda lucida and Nauclea latifolia against S. mansoni were evaluated in ...
Enhanced circulating ILC2s and MDSCs may contribute to ensure maintenance of Th2 predominant in patients with lung cancer

qWu, Yumin; Yan, Yulan; Su, Zhaoliang; Bie, Qingli; Chen, Xiaobo; Barnie, Prince Amoah; Guo, Qi; Wang, Shengjun; Xu, Huaxi (University of Cape Coast, 2016)

Group 2 innate lymphoid cells (ILC2s) were demonstrated to be involved in the initiation and coordination of type 2 T helper cell (Th2) responses. Myeloid-derived suppressor cells (MDSCs) have received a great deal of ...
Effects of malaria in pregnancy (mip) on pregnancy development and its outcome: a Critical review

Djabanor, Joshua; Quansah, Elvis; Asante, Du-Bois (University of Cape Coast, 2016)

Malaria is the most important tropical parasitic infection in humans all over the world, and very common in developing countries especially in the tropical zones. The protozoan parasites Plasmodium falciparum, P. vivax, ...
Effect of pre-existing Schistosoma haematobium infection on Plasmodium berghei multiplications in imprinting control region mice

Amoani, Benjamin; Ameyaw, Elvis Ofori; Asante, Du-Bois; Armah, Francis Ackah; Prah, James; Botchey, Collins Paa Kwesi; Boampong, Johnson Nyarko (University of Cape Coast, 2014)

Objective: To investigate the effect of pre-existing Schistosoma haematobium (S. haematobium) infection on malaria disease severity. Methods: The study involved the use of twenty-five imprinting control region mice, fifteen ...
Ecological zones rather than molecular forms predict genetic differentiation in the malaria vector anopheles gambiaes.s. in Ghana

Yawson, Alexander E.; Weetman, David; Wilson, Michael D.; Donnelly, Martin . (University of Cape Coast, 2016)

The malaria mosquito Anopheles gambiaes.s. is rapidly becoming a model for studies on the evolution of reproductive isolation. Debate has centered on the taxonomic status of two forms (denoted M and S) within the nominal ...
Dual faced HMGB1 plays multiple roles in cardiomyocyte senescence and cardiac infammatory injury

Lu, Hongxiang; Zhang, Zhenzhen; Barnie, Prince Amoah; Su, Zhaoliang (University of Cape Coast, 2019)

High mobility group box 1 (HMGB1) is constitutively expressed by many cells. In cells, HMGB1 is a transcription factor or transcription enhancer that is involved in nucleosome sliding, DNA repair, V(D)J recombination, ...
Down regulation of Runx3 is closely related to the decreased Th1-associated factors in patients with gastric carcinoma

Li, Yazhen; Ji, Xiaoyun; Su, Zhaoliang; Tong, Jia; Xia, Sheng; Chen, Xiaobo; Lu, Ping; Barnie, Prince Amoah; Wang, Shengjun; Huang, Xinxiang; Xu, Huaxi (University of Cape Coast, 2014-10-01)

Abstract Runt-related transcription factor 3 (Runx3) is a tumor-suppressor gene and lays an important role in immune regulation, whose reduced expression may lay an important role in the development and progression of ...
Down-regulation of Id1 and Id3 genes affects growth and survival of human umbilical vein endothelial cells (huvecs)

Kyei, Foster; Asante, Du-Bois; Edekor, Juliet Ama Mawusi; Sarpong, Esther; Gavor, Edem; Konja, Daniels (University of Cape Coast, 2015)

Inhibitors of DNA (Id) proteins have been implicated in cell growth, cell cycle control, apoptosis and angiogenesis. Studies reveal that Id1 and Id3 may be required for angiogenesis in adult tissues. This work aimed at ...
Distribution of Hairs on the phalanges of hands among Ghanaians

Aboagye, Benjamin; Tsegah, Korantema Mawuena; Ussif, Abdala Mumuni (University of Cape Coast, 2013)

Aim. Te study intended to observe the frequency and pattern of distribution of phalangeal hairs on the hands of Ghanaians. Material and methods. A total of 1040 healthy consenting individuals (529 females and 511 males) ...
Development of efflux pumps and inhibitors (epis) in A. baumanii

Xing, Lidan; Barnie, Prince Amoah; Su, Zhaoliang; Xu, Huaxi (University of Cape Coast, 2014)

Over the past three decades, Acinetobacter baumannii has emerged as an important nosocomial pathogen worldwide. Certain strains of A baumannii are now resistant to many common antimicrobial agents, including fuoroquinolone, ...
Detection of human papillomavirus genotypes and epstein-barr irus in nasopharyngeal carcinomas at the Korle-bu teaching hospital, Ghana

Asante, Du-Bois; Asmah, Richard Harry; Adjei, Andrew Anthony; Kyei, Foster; Simpong, David Larbi; Brown, Charles Addoquaye; Gyasi, Richard Kwasi (University of Cape Coast, 2017-03-21)

Nasopharyngeal carcinomas (NPC) are endemic in Far East Asia and commonly harbour Epstein-Barr Virus (EBV) which is known to serve as a key oncogenic promoter. Human papillomavirus (HPV) is known to contribute to the ...
CpG‑oligodeoxynucleotides suppress the proliferation of A549 lung adenocarcinoma cells via toll‑like receptor 9 signaling and upregulation of Runt‑related transcription factor 3 expression

Barnie, Prince Amoah; Zhang, Pan; Lu, Ping; Chen, Xiaobo; Su, Zhaoliang; Wang, Shengjun; Xu, Huaxi (University of Cape Coast, 2014)

The aim of the present study was to investigate the effect of CpG-oligodeoxynucelotides (CpG-ODN) on the proliferation of the A549 human lung adenocarcinoma cell line and the expression of Runt-related transcription factor ...

Now showing items 61-80 of 94

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