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Evaluating the effect of an aqueous extract of Pistia stratiotes Linn (Araceae) on tear secretion and tear film stability in ICR mice

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dc.contributor.author Abokyi, Samuel
dc.contributor.author Koffuor, George Asumeng
dc.contributor.author Ofori, Elvis Ameyaw
dc.contributor.author Thomford, Ama Kyerea
dc.contributor.author Osei, Kweku Antwi
dc.date.accessioned 2021-06-28T09:42:35Z
dc.date.available 2021-06-28T09:42:35Z
dc.date.issued 2014
dc.identifier.issn 23105496
dc.identifier.uri http://hdl.handle.net/123456789/5529
dc.description 6p:, ill. en_US
dc.description.abstract Management of allergic conjunctivitis with conventional anti-allergic drugs usually cause the discomfort of dry eyes. This study, therefore, sought to evaluate the effect of Pistia stratiotes, a herbal remedy with anti-allergic properties, on tear secretion and tear film stability. ICR mice were grouped and treated with 5 mg/kg cetirizine, 10 mg/kg prednisolone, 100 mg/ kg leaf extract of P. stratiotes (LEPS), or 2 ml/kg normal saline per os for 7 consecutive days. With the phenol red thread test and the determination of fluorescein tear film break-up time, tear secretion and tear film stability before and after drug interventions were determined. Results recorded indicated that tear secretion and tear film stability declined significantly with cetirizine treatment (1.188 ± 0.4369 mm; P ≤ 0.05, and 2.688 ± 0.6185 s; P ≤ 0.001 respectively), while only tear secretion reduced significantly (P ≤ 0.05) in mice treated with prednisolone (0.9380 ± 0.4422 mm). Treatment with LEPS showed no significant effect (P > 0.05) on tear secretion and tear film stability (0.7050 ± 0.4236 mm, and 0.9790 ± 0.6145 s respectively); comparable to normal saline treatment. Per the findings, Pistia stratiotes does not affect tear secretion and tear film stability and hence is not likely to exhibit the adverse effect of dry eyes, as conventional anti-allergic drugs do, in the management of allergic conjunctivitis en_US
dc.language.iso en en_US
dc.publisher University of Cape Coast en_US
dc.subject Dry eyes en_US
dc.subject Phenol red thread test en_US
dc.subject Fluorescein tear film en_US
dc.subject Break-up time en_US
dc.subject Allergic Conjunctivitis en_US
dc.title Evaluating the effect of an aqueous extract of Pistia stratiotes Linn (Araceae) on tear secretion and tear film stability in ICR mice en_US
dc.type Article en_US


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