α-Synuclein is a protein implicated in the etiopathogenesis of Parkinson’s disease (PD). AAV1/2-driven overexpression of human mutated A53T-α-synuclein in rat and monkey substantia nigra (SN) induces degeneration of ...

Purpose: Available evidence suggests widespread ocular problems in Ghana, including more than 200,000 cases of blindness in a country of 20 million, which is about the highest rate in any African country. The purpose of ...

Although blurred vision from quinine toxicity is well documented in literature, an acute effect leading to blindness is infrequently reported. We report a case of sudden bilateral blindness in a child after quinine treatment ...

Acute kidney injury (AKI) is a highly fatal complication of malaria. We used the Kidney Disease Improving Global Outcomes (KDIGO) and Pediatric Risk, Injury, Failure, Loss, End-Stage Kidney Disease (pRIFLE) guidelines ...

Abstract: Despite great strides being achieved in improving cancer patients’ outcomes through better therapies and combinatorial treatment, several hurdles still remain due to therapy resistance, cancer recurrence and ...

Background Advanced maternal age (AMA) has been associated with negative pregnancy outcomes. Oxidative stress (OS) and defective placental dysfunction are contributing factors. This study determined the association ...

Context: Polyscias fruticosa (L.) Harms (Araliaceae) is used as a traditional remedy for asthma in Ghana. Objective: The objective of this study is to establish the anti-asthmatic property and a possible mode of activity ...

Background: Polyscias fruticosa is a plant used in the traditional management of asthma in Ghana. Aim: This study evaluated the anti-inflammatory property of an ethanolic leaf extract of Polyscias fruticosa and safety ...