University of Cape Coast Institutional Repository

Quality assessment of rtemether-Lumefantrine Samples and Artemether Injections Sold in the Cape Coast Metropolis

Show simple item record Prah, James Ameyaw, Elvis Ofori Afoakwah, Richmond Fiawoyife, Patrick Oppong-Danquah, Ernest Boampong, Johnson Nyarko 2021-07-02T12:10:40Z 2021-07-02T12:10:40Z 2015
dc.identifier.issn 23105496
dc.description 7p:, ill. en_US
dc.description.abstract Most prescribers and patients in Ghana now opt for the relatively expensive artemether/lumefantrine rather than artesunate amodiaquine due to undesirable side effects in the treatment of uncomplicated malaria. The study sought to determine the existence of substandard and/or counterfeit artemether-lumefantrine tablets and suspension as well as artemether injection on the market in Cape Coast. Six brands of artemether-lumefantrine tablets, two brands of artemether-lumefantrine suspensions, and two brands of artemether injections were purchased from pharmacies in Cape Coast for the study. Te mechanical properties of the tablets were evaluated. The samples were then analyzed for the content of active ingredients using High Performance Liquid Chromatography with a variable wavelength detector. None of the samples was found to be counterfeit. However, the artemether content of the samples was ariable (93.22%−104.70% of stated content by manufacturer). The lumefantrine content of the artemether/lumefantrine samples was also ariable (98.70%–111.87%). Seven of the artemether-lumefantrine brands passed whilst one failed the International Pharmacopoeia content requirements. All brands of artemether injections sampled met the International Pharmacopoeia content requirement. Te presence of a substandard artemether-lumefantrine suspension in the market should alert regulatory bodies to be more vigilant and totally flush out counterfeit and substandard drugs from the Ghanaian market. en_US
dc.language.iso en en_US
dc.publisher University of Cape Coast en_US
dc.title Quality assessment of rtemether-Lumefantrine Samples and Artemether Injections Sold in the Cape Coast Metropolis en_US
dc.type Article en_US

Files in this item

This item appears in the following Collection(s)

Show simple item record

Search UCC IR

Advanced Search


My Account