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Relative Susceptibilities of BO Blood Groups of Plasmodium falciparum Malaria in Ghana

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dc.contributor.author Afoakwah, Richmond
dc.contributor.author Aubyn, Edmond
dc.contributor.author Prah, James
dc.contributor.author Nwaefuna, Ekene Kwabena
dc.contributor.author Boampong, Johnson N.
dc.date.accessioned 2021-07-05T09:44:15Z
dc.date.available 2021-07-05T09:44:15Z
dc.date.issued 2015
dc.identifier.issn 23105496
dc.identifier.uri http://hdl.handle.net/123456789/5583
dc.description 5p:, ill. en_US
dc.description.abstract The clinical outcome of falciparum malaria in endemic areas is influenced by erythrocyte polymorphisms including the ABO blood groups. Studies have reported association of ABO blood group to resistance, susceptibility, and severity of P. falciparum malaria infection. Individuals with blood group “A” have been found to be highly susceptible to falciparum malaria whereas blood group “O” is said to confer protection against complicated cases. We analyzed samples from 293 young children less than six years old with malaria in the Korle-Bu Teaching Hospital in Accra, Ghana. It was observed that group O was present in about 16.1% of complicated cases weighed against 40.9% of uncomplicated controls. Individuals with complicated malaria were about twice likely to be of blood groups A and B compared to group O (A ersus O, OR = 1.90, 95% CI = 1.59–2.26,� < 0.0001; B ersus O, OR = 1.82. 95% CI =1.57–2.23,� < 0.0001). Blood group O participants with complicated diseases had low parasitaemia compared to the other blood groups (� < 0.0001). Tis may give blood group O individuals a survival advantage over the other groups in complicated malaria as suggested. Participants with complicated falciparum malaria were generally anaemic and younger than those with uncomplicated disease en_US
dc.language.iso en en_US
dc.publisher University of Cape Coast en_US
dc.title Relative Susceptibilities of BO Blood Groups of Plasmodium falciparum Malaria in Ghana en_US
dc.type Article en_US


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