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Evaluating Muco-suppressant, Anti-tussive and Safety Profile of Polyscias fruticosa (L.) Harms (Araliaceae) in Asthma Management

Show simple item record Koffuor, George Asumeng Boye, Alex Ofori-Amoah, Jones Kyei, Samuel Nouoma, Cyrille Kablan Agyemang Prempeh, Debrah 2022-06-01T15:49:18Z 2022-06-01T15:49:18Z 2015-08
dc.identifier.issn 23105496
dc.description 11p:, ill. en_US
dc.description.abstract Polyscias fruticosa is been used in Ghanaian folkloric medicine for the management of asthma and its related complications. Aim: This study evaluated the muco-suppressant, anti-tussive, and safety profile of an ethanolic leaf extract of Polyscias fruticosa in its use as an anti-asthmatic. Place and Duration of Study: Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, KNUST, Kumasi, Ghana and the School of Physical Sciences, University of Cape-Coast, Cape-Coast, Ghana; between December, 2013 and May, 2014. Methodology: Preliminary phytochemical screening was carried out on the extract. Ammonium chloride-induced tracheal mucus phenol red secretion in ICR mice and the suppression of citric acid-induced cough in Dunkin-Hartley guinea pigs were determined after treatment of experimental animals with 100 mg/kg sodium cromoglycate, or 20 mg/kg dihydrocodeine respectively, as well as with 100, 250, or 500 mg/kg of the extract. A 100, 250, and 500 mg/kg dose of the extract was administered daily for 28 days to groups of guinea pigs to establish a safety profile in a sub-chronic toxicity study. Results: Phytochemical screening revealed the presence of saponins and cyanogenetic glycosides, alkaloids, and sterols. The extract significantly inhibited (P ≤ .01 - 0.001) tracheal mucus phenol red secretion, and suppression of citric acid-induced cough. There were no significant changes in body weight, haematological profile, as well as liver and kidney functions in the sub-chronic toxicity study. Conclusion: The findings indicate that the ethanolic leaf extract of Polyscias fruticosa has mucosuppressant and anti-tussive properties, and is safe to use; hence a suitable adjunct/remedy for the management of asthma. en_US
dc.language.iso en en_US
dc.publisher University of Cape Coast en_US
dc.subject Asthma en_US
dc.subject tracheal mucus phenol red secretion en_US
dc.subject citric acid-induced cough en_US
dc.subject liver and kidney function tests en_US
dc.title Evaluating Muco-suppressant, Anti-tussive and Safety Profile of Polyscias fruticosa (L.) Harms (Araliaceae) in Asthma Management en_US
dc.type Article en_US

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