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Anti-Asthmatic Property and Possible Mode of Activity of An Ethanol Leaf Extract of Polyscias Fruticosa

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dc.contributor.author Koffuor, George Asumeng
dc.contributor.author Boye, Alex
dc.contributor.author Kyei, Samuel
dc.contributor.author Ofori-Amoah, Jones
dc.contributor.author Asiamah, Emmanuel Akomanin
dc.contributor.author Barku, Atsu
dc.contributor.author Acheampong, Jacqueline
dc.contributor.author Amegashie, Elikplim
dc.contributor.author Awuku, Albert Kumi
dc.date.accessioned 2022-06-06T10:02:10Z
dc.date.available 2022-06-06T10:02:10Z
dc.date.issued 2015-10
dc.identifier.issn 23105496
dc.identifier.uri http://hdl.handle.net/123456789/8274
dc.description 11p:, ill. en_US
dc.description.abstract Context: Polyscias fruticosa (L.) Harms (Araliaceae) is used as a traditional remedy for asthma in Ghana. Objective: The objective of this study is to establish the anti-asthmatic property and a possible mode of activity of an ethanol leaf extract of P. fruticosa (PFE). Materials and methods: The time (min) for pre-convulsive dyspnea, and time for recovery, after sensitization with 150 mg OVA and induction of bronchospasm with 1% acetylcholine or histamine in normal, and 100, 250, and 500 mg/kg PFE-treated Dunkin Hartley guinea pigs, were recorded. Atropine (0.1 mg), mepyramine (0.1 mg), and PFE (1 mg) effect on a contractile response of 2.0 10 2 mg/ml acetylcholine and 5.8 10 2 mg/ml histamine on the isolated guinea pig ileum was investigated. Cytological and histological studies were conducted using guinea pig peritoneal mast cells and mesenteric cells, respectively, to establish PFE effect on compound 48/80-induced mast cell degranulation. Results: PFE (100–500 mg/kg) prolonged the onset of pre-convulsive dyspnea by 76.1–180.2% (p 0.01–0.001), and decreased recovery time by 71.9–78.5% (p 0.01–0.001). It also enhanced percentage protection against histamine-induced bronchospasm by 15.8–80.1-fold (p 0.05–0.01), and decreased percentage recovery time 2.5–3.3-fold (p 0.05–0.01). PFE significantly inhibited (60.4 ± 8.3%) contractile responses of histamine and produced significant inhibition (56–79%: p 0.001) of mast cell degranulation. Conclusion: PFE has anti-asthmatic, antihistaminic, and mast cell stabilization effect making it useful in traditional asthma management. en_US
dc.language.iso en en_US
dc.publisher University of Cape Coast en_US
dc.subject Antihistamine en_US
dc.subject Asthma en_US
dc.subject Mast cell stabilization en_US
dc.subject Peritoneal mast cells en_US
dc.subject Pre-convulsive dyspnea en_US
dc.title Anti-Asthmatic Property and Possible Mode of Activity of An Ethanol Leaf Extract of Polyscias Fruticosa en_US
dc.type Article en_US


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