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Anti-uveitogenic effect of Xylopic acid in Sprague-Dawley rats

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dc.contributor.author Kyei, Samuel
dc.contributor.author Ameyaw, Elvis Ofori
dc.contributor.author Koffuor, George Asumeng
dc.contributor.author Boampong, Johnson Nyarko
dc.contributor.author Woode, Eric
dc.contributor.author Abueh, Blessing Barilee
dc.contributor.author Osei, Owusu-Afriyie
dc.contributor.author Karikari, Akua Afriyie
dc.date.accessioned 2022-06-06T11:05:11Z
dc.date.available 2022-06-06T11:05:11Z
dc.date.issued 2014
dc.identifier.issn 23105496
dc.identifier.uri http://hdl.handle.net/123456789/8279
dc.description 8p:, ill. en_US
dc.description.abstract Uveitis, intraocular inflammatory disorder is one of the leading causes of blindness in the world. This study investigated the curative effect of xylopic acid on endotoxin-induced uveitis in Sprague-Dawley rats. Uveitis was induced in rats by injecting 110 μg lipopolysaccharide (LPS) subcutaneously. Clinical signs of uveitis were assessed with a slit lamp. Polymorphonuclear neutrophils and total proteins in the aqueous humour of the eyes were estimated and these markers of inflammation were elevated in the control groups. Histopathological assessments of inflammation in the ocular tissues were also performed. There were significant reductions (P≤ 0.05) in vasodilatation of iris vessels, exudation, polymorphonuclear neutrophils and total proteins in the aqueous humour of xylopic acid and prednisolone treated uveitic rats compare to the untreated (control). Histopathological assessments revealed resolution of uveitis in treatment groups but not the untreated. This shows that oral administration of xylopic acid has ocular anti-inflammatory effect in Sprague-Dawley rats. en_US
dc.language.iso en en_US
dc.publisher University of Cape Coast en_US
dc.subject Uveitis en_US
dc.subject Lipopolysaccharide en_US
dc.subject Anti-Inflammatory en_US
dc.subject Xylopic acid en_US
dc.title Anti-uveitogenic effect of Xylopic acid in Sprague-Dawley rats en_US
dc.type Article en_US


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