Abstract:
In the present study Aspirin loaded Ethyl cellulose nanoparticles
were prepared by solvent evaporation method in the presence of Tween
20 as emulsifying agent and ethyl acetate as organic solvent. Three
formulations were prepared by varying the concentration of polymer
and the influence of process parameters such as solvent mixture,
composition, concentration of the emulsifying agent and speed of
stirring has been examined. All the three formulations are evaluated for
drug content, product yield, particle size, entrapment efficiency and
loading capacity. Entrapment efficiency and loading capacity were
determined by ELTEK NP 400 Ultracentrifuge. The particle size and
stability of the formulations were determined by HORIBA SZ-100 series particle size
analyzer. Entrapment efficiencies were found to be 93.4%, 96.2% and 98.6% and the loading
capacities were found to be 32.22%, 34.6% and 35.77% respectively for F1, F2 and F3
formulations. Comparative study was performed to determine the best method for the
preparation of Aspirin loaded ethyl cellulose nanoparticles. From the evaluation studies it
was observed that F2 formulation was giving promising results. The average particle size of
the best formulation, F2 was found to be 444.5nm and zeta potential was found to be
41.5mV. Invitro drug release studies were performed to determine the sustain release nature
of the formulation and drug release was sustained up to 12hrs for nanoparticles prepared by
F2 formulation.
