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Effects of Three Herb-Based Alcoholic Beverages Manufactured in Ghana on Sperm Characteristics and Reproductive Hormones in Rats

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dc.contributor.author Biney, Robert P.
dc.contributor.author Agyei, Phyllis E. Owusu
dc.contributor.author Ameyaw, Elvis O.
dc.contributor.author Afortude, John K.
dc.contributor.author Henneh, Isaac T.
dc.contributor.author Obese, Ernest
dc.contributor.author Nyarko, Samuel Badu
dc.contributor.author Ekor, Martins
dc.date.accessioned 2022-07-06T11:58:46Z
dc.date.available 2022-07-06T11:58:46Z
dc.date.issued 2020-02
dc.identifier.issn 23105496
dc.identifier.uri http://hdl.handle.net/123456789/8417
dc.description 9p:, ill. en_US
dc.description.abstract Background: Advertisements of most alcoholic beverages in Ghana persuasively entice con- sumers with herbal constituents believed to enhance sexual performance, although, alco- hol has negative effect onfertility. The impact of herbal constituents in these alcoholic bev- erages on the known negative effects of alcohol on fertility remains to be evaluated. This study evaluated the effects of three alcoholic beverages manufactured in Ghana on male reproductive function in rats. Methods: Male Sprague-Dawley rats received 0.5, 2.5 or 5 ml/kg of 3 herb-based alcoholic beverages (Brand A, B & C), 42% v / v ethanol or distilled water p.o. for 21 days. On day 22, blood was collected and assayed for serum prolactin, testosterone and, hematological parameters. Testes were removed for histology and sperm from the cauda epididymis an- alyzed for sperm count, motility and morphology. Total antioxidant capacity of the testes was determined. Results: The three alcoholic beverages did not cause any changes in hematological param- eters and relative weight of the testes. However, Brand C reduced epididymal sperm count and increased serum prolactin and induced loss of germinal epithelial cells, necrosis, inter- tubular edema in seminiferous tubules and lipid and fluid accumulation in the Sertoli cells. Both Brands A and B caused tubular atrophy and enlarged spermatogonia at 5 ml/kg. All three brands significantly ( p < 0.001) reduced sperm motility and serum testosterone, al- though they increased total antioxidant capacity. Conclusion: The herb-based alcoholic beverages evaluated did not enhance or exert a ben- eficial effect on male reproductive function but rather demonstrated spermatotoxic prop- erties irrespective of the presence of medicinal plants. en_US
dc.language.iso en en_US
dc.publisher University of Cape Coast en_US
dc.subject Spermatotoxicity en_US
dc.subject Alcoholism en_US
dc.subject Herbal medicines en_US
dc.subject Herb-based alcoholic beverages en_US
dc.subject Male reproduction en_US
dc.title Effects of Three Herb-Based Alcoholic Beverages Manufactured in Ghana on Sperm Characteristics and Reproductive Hormones in Rats en_US
dc.type Article en_US


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