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Erythroivorensin: A Novel Anti-inflammatory Diterpene from the Root-bark of Erythrophleum Ivorense (A Chev.)

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dc.contributor.author Armah, Francis A.
dc.contributor.author Annan, Kofi
dc.contributor.author Mensah, Abraham Y.
dc.contributor.author Amponsah, Isaac K.
dc.contributor.author Tocher, Derek A.
dc.contributor.author Habtemariam, Solomon
dc.date.accessioned 2022-07-07T09:51:08Z
dc.date.available 2022-07-07T09:51:08Z
dc.date.issued 2015-06
dc.identifier.issn 23105496
dc.identifier.uri http://hdl.handle.net/123456789/8423
dc.description 6p:, ill. en_US
dc.description.abstract The stem- and root-bark of Erythrophleum ivorense (A Chev., family, Fabaceae) are routinely employed in the West African traditional medicine to treat inflammation and a variety of other disease conditions. Although the chemistry and pharmacology of cassaine-type diterpene alkaloids isolated from the stem-bark of the plant are fairly established, the root-bark has not yet been investigated. In the present study, the crude aqueous-alcohol extract of the root-bark was demonstrated to display a time- and dose (30–300 mg/kg p.o.)-dependent antiinflammatory effect in chicks. Comprehensive chromatographic analysis coupled with spectroscopic and X-ray study further allowed the assignment of one of the major anti-inflammatory constituents as a novel cassainetype diterpene, erythroivorensin. The other major constituents were known anti-inflammatory compounds: a triterpene, betulinic acid and a flavonoid, eriodictyol. The dose (10–100 mg/kg p.o.)-dependent antiinflammatory effects of the three compounds were either comparable or more significant than the positive control, diclofenac. en_US
dc.language.iso en en_US
dc.publisher University of Cape Coast en_US
dc.subject Erythrophleum ivorense en_US
dc.subject Fabaceae en_US
dc.subject Erythroivorensin en_US
dc.subject Betulinic acid en_US
dc.subject Eriodictyol en_US
dc.subject Anti-inflammatory en_US
dc.title Erythroivorensin: A Novel Anti-inflammatory Diterpene from the Root-bark of Erythrophleum Ivorense (A Chev.) en_US
dc.type Article en_US


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