University of Cape Coast Institutional Repository

Short Report: Detection of Plasmodium falciparum Histidine-rich Protein II in Saliva of Malaria Patients

Show simple item record

dc.contributor.author Wilson, Nana O.
dc.contributor.author Adjei, Andrew A.
dc.contributor.author Anderson, Winston
dc.contributor.author Baidoo, Stella
dc.contributor.author Stiles, Jonathan K.
dc.date.accessioned 2022-07-12T10:41:01Z
dc.date.available 2022-07-12T10:41:01Z
dc.date.issued 2008
dc.identifier.issn 23105496
dc.identifier.uri http://hdl.handle.net/123456789/8437
dc.description 3p:, ill. en_US
dc.description.abstract Detection of Plasmodium falciparum parasites in patients with malaria necessitates drawing blood, which increases the risk of accidental infections and is poorly accepted in communities with blood taboos. Thus, non-invasive, cost-effective malaria tests that minimize the need for blood collection are needed. Plasmodium falciparum histidine-rich protein II (PfHRP II) levels in plasma and saliva were compared in malaria–positive and –negative patients in Ghana. Plasma and saliva obtained from 30 thick-film positive and 10 negative children were evaluated for PfHRP II by ELISA. Among the 30 children with positive blood smear, 16 (53%) were PfHRP II positive in plasma and 13 (43%) had PfHRP II positive saliva. The sensitivity of PfHRP II detection was 53% for plasma and 43% for saliva. The specificity was 100% with no false positive for both plasma and saliva when compared with blood smear. Thus, rapid detection of PfHRP II antigen in saliva may be a useful non-invasive and cost-effective malaria diagnostic technique. en_US
dc.language.iso en en_US
dc.publisher University of Cape Coast en_US
dc.title Short Report: Detection of Plasmodium falciparum Histidine-rich Protein II in Saliva of Malaria Patients en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search UCC IR


Advanced Search

Browse

My Account