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Indigenous Medicinal Plants as Biofilm Inhibitors for the Mitigation of Antimicrobial Resistance

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dc.contributor.author Ampofo, Elikplim Kwesi
dc.contributor.author Amponsah, Isaac Kingsley
dc.contributor.author Asante-Kwatia, Evelyn
dc.contributor.author Armah, Francis Ackah
dc.contributor.author Atchoglo, Philip Kobla
dc.contributor.author Mensah, Abraham Yeboah
dc.date.accessioned 2022-07-13T14:21:04Z
dc.date.available 2022-07-13T14:21:04Z
dc.date.issued 2020-10
dc.identifier.issn 23105496
dc.identifier.uri http://hdl.handle.net/123456789/8449
dc.description 10p:, ill. en_US
dc.description.abstract )e majority of indigenes in the rural areas of Ghana use herbal medicines for their primary health care. In this study, an ethnobotanical survey was undertaken to document medicinal plants used by traditional healers in the Ejisu-Juaben district in the Ashanti region of Ghana to treat infections and to further investigate the antibiofilm formation properties of selected plants in resisting pathogenic bacteria. Seventy medicinal plants used by traditional practitioners for the treatment of skin infections and wounds were documented from the ethnobotanical survey. Forty out of the seventy plants were collected and their methanol extracts evaluated for antimicrobial activity by the agar diffusion assay. Extracts that showed antibacterial activity were tested for biofilm inhibitory activity, and the most active plant was subsequently purified to obtain the active constituents. Biofilm formation was significantly mitigated by petroleum ether, ethyl acetate, and methanol extracts of Holarrhena floribunda stem bark. Bioassayguided fractionation of an alkaloidal extract prepared from the methanol fraction led to the isolation of three steroidal alkaloids, namely, holonamine, holadienine, and conessine. )e isolated compounds demonstrated varying degrees of biofilm formation inhibitory properties. )e current study reveals that screening of indigenous medicinal plants could unravel potential leads to salvage the declining efficacy of conventional antibiotics. Holarrhena floribunda stem bark extract has strong biofilm formation inhibition properties, which could be attributed to the presence of steroidal alkaloids. en_US
dc.language.iso en en_US
dc.publisher University of Cape Coast en_US
dc.title Indigenous Medicinal Plants as Biofilm Inhibitors for the Mitigation of Antimicrobial Resistance en_US
dc.type Article en_US


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