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Anticonvulsant activity of Pseudospondias microcarpa (A. Rich) Engl. hydroethanolic leaf extract in mice: The role of excitatory/inhibitory neurotransmission and nitric oxide pathway

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dc.contributor.author Adongoa, Donatus W.
dc.contributor.author Manteb, Priscilla K.
dc.contributor.author Kukuiac, Kennedy K.E.
dc.contributor.author Bineyd, Robert P.
dc.contributor.author Boakye-Gyasib, Eric
dc.contributor.author Bennehb, Charles K.
dc.contributor.author Ameyawe, Elvis O.
dc.contributor.author Eric Woode
dc.date.accessioned 2023-09-28T15:56:48Z
dc.date.available 2023-09-28T15:56:48Z
dc.date.issued 2017-05-10
dc.identifier.uri http://hdl.handle.net/123456789/8655
dc.description.abstract Ethnopharmacological relevance: Pseudospondias microcarpa (A. Rich) Engl. is a plant used for managing various diseases including central nervous system disorders. Aim of the study: This study explored the anticonvulsant activity of P. microcarpa hydroethanolic leaf extract (PME) as well as possible mechanism(s) of action in animal models. Methods: Effects of PME was assessed in electroconvulsive (the maximal electroshock and 6-Hz seizures) and chemoconvulsive (pentylenetetrazole-, picrotoxin-, isoniazid-, 4-aminopyridine-, and strychnine-induced seizures) models of epilepsy. In addition, effect of the extract on the nitric oxide pathway and GABAA receptor complex was evaluated. Results: The extract (30, 100 and 300 mg kg−1, p.o.) significantly delayed the onset as well as decreased the duration and frequency of pentylenetetrazole-, picrotoxin- and strychnine-induced seizures. In addition, PME pre-treatment significantly improved survival in the 4-aminopyridine- and isoniazid-induced seizure tests. Furthermore, the extract protected against 6-Hz psychomotor seizures but had no effect in the maximal electroshock test. The anticonvulsant effect of PME (100 mg kg−1, p.o.) was also reversed by pre-treatment with flumazenil, L-arginine or sildenafil. However, L-NAME or methylene blue (MB) augmented its effect. Conclusion: Results show that PME has anticonvulsant activity and may probably be affecting GABAergic, glycinergic, NMDA, K+ channels and nitric oxide-cGMP pathways to exert its effect. en_US
dc.language.iso en en_US
dc.publisher University of Cape Coast en_US
dc.title Anticonvulsant activity of Pseudospondias microcarpa (A. Rich) Engl. hydroethanolic leaf extract in mice: The role of excitatory/inhibitory neurotransmission and nitric oxide pathway en_US
dc.type Article en_US


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