University of Cape Coast Institutional Repository

Antinociceptive Ecdysteroids and Other Constituents of Palisota hirsuta K. Schum (Commelinaceae)

Show simple item record

dc.contributor.author Sarpong, Francis Mainoo
dc.contributor.author Armah, Francis Ackah
dc.contributor.author Amponsah, Isaac Kingsley
dc.contributor.author Atchoglo, Philip Kobla
dc.date.accessioned 2023-09-28T19:09:13Z
dc.date.available 2023-09-28T19:09:13Z
dc.date.issued 2016-10
dc.identifier.uri http://hdl.handle.net/123456789/8667
dc.description.abstract The root of Palisota hirsuta is used in Ghana and other West African countries for the treatment of various disease conditions such as rheumatoid arthritis (also in other inflammatory and painful conditions), infertility in females, anaemia, and dysentery. The current study sought to evaluate the anti-nociceptive effect of the hydroethanolic root extract and compounds isolated from Palisota hirsuta. Mice were used for studying the antinociceptive activity of P. hirsuta extracts and isolates at doses of 10-300 mgkg-1p.o and 10- 30 mgkg-1 respectively using the Formalin Induced paw licking model. The total crude extract, methanolic and petroleum ether fractions showed analgesic activity in a dose-dependent manner for both the early and late phases. Three isolates, a fatty acid mixture, 20-hydroxyecdysone and an uncharacterized ecdysteroid (PH V) were obtained from the methanol fractions with significant activity. 20-hydroxyecdysone exhibited a dose-dependent inhibition of the nociception for both the early and late phases; 71.39±9.19% and 89.19±3.81% respectively. PH V showed significant activity between the early and late phases of inhibition as compared to the reference drug morphine. The present study has given scientific credence to the use of the roots of P. hirsuta for the mitigation of pain and established its antinociceptive constituents. en_US
dc.language.iso en en_US
dc.publisher University of Cape Coast en_US
dc.subject Formalin en_US
dc.subject Nociceptive en_US
dc.subject Inhibition en_US
dc.subject Isolates en_US
dc.subject ecdysteroids en_US
dc.title Antinociceptive Ecdysteroids and Other Constituents of Palisota hirsuta K. Schum (Commelinaceae) en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search UCC IR


Advanced Search

Browse

My Account