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Differential response in lipid levels of type 2 diabetics and non-diabetic controls to falciparum malaria

Show simple item record Acquah, Samuel Eghan Jnr, Benjamin Ackon Bawa, Salifu Boampong, Johnson Nyarko 2023-09-29T13:41:34Z 2023-09-29T13:41:34Z 2018-08-30
dc.description.abstract Objective: To investigate the effects of falciparum malaria on lipid profile and atherogenic indices of type 2 diabetics and non-diabetic adults in the Central Region of Ghana. Methods: Plasma lipid profile comprising total cholesterol (CHOL), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL) and triglycerides (TG) were determined in 100 type 2 diabetics and 100 non-diabetic controls before and during falciparum malaria using the BT3000 autoanalyzer in a prospective case control study design. Atherogenic indices were computed. Results: At baseline, diabetics recorded significantly (P < 0.05) lower level of LDL but higher levels of CHOL/LDL and TG/HDL ratios than controls. LDL correlated (P < 0.05) positively but negatively with CHOL and HDL respectively in the two study groups. During malaria, diabetics exhibited higher (P < 0.05) levels of CHOL and TG but lower level of HDL. Non-diabetic controls had malaria-induced elevated level in TG only. The positive correlation between LDL and CHOL was maintained in the two study groups. The TG levels of diabetics correlated (P < 0.05) positively with LDL and HDL during malaria. In the case of controls, a positive (P < 0.05) correlation was found between LDL and HDL during falciparum malaria. Conclusion: Falciparum malaria modified the associations among the various components of lipid profile and elevated TG levels of diabetics and non-diabetic controls. en_US
dc.language.iso en en_US
dc.publisher University of Cape Coast en_US
dc.subject Falciparum malaria en_US
dc.subject type 2 diabetes en_US
dc.subject lipid profile en_US
dc.subject atherogenic indices en_US
dc.title Differential response in lipid levels of type 2 diabetics and non-diabetic controls to falciparum malaria en_US
dc.type Article en_US

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