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In vivo antiplasmodial and in vitro antioxidant properties of stem bark extracts of Haematostaphis barteri

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dc.contributor.author Boampong, Johnson Nyarko
dc.contributor.author karikari, Akua Afryie
dc.contributor.author Ameyaw, Elvis Ofori
dc.date.accessioned 2023-09-30T13:29:38Z
dc.date.available 2023-09-30T13:29:38Z
dc.date.issued 2015-02-03
dc.identifier.uri http://hdl.handle.net/123456789/8787
dc.description.abstract Objective: To evaluate the antimalarial and antioxidant properties of stem bark extracts of Haematostaphis barteri (H. barteri). Methods: The prophylactic activity of the plant was performed by dosing mice with sulfadoxine-pyrimethamine (1.2 mg/kg), aqueous extract (30, 100, 300 mg/kg) and dichloromethane/methanol (D/M) (30, 100, 300 mg/kg) extracts of H. barteri for 3 days. On the 4th day, the mice were inoculated with Plasmodium berghei. The parasite density was estimated for each mouse 72 h post-parasite inoculation. The curative activity of the plant was also performed by inoculating mice with Plasmodium berghei. Three days later, they were treated with artemether-lumefantrine (4 mg/kg), aqueous and D/M extracts of H. barteri stem bark for 5 days. The in vitro antioxidant property of the aqueous extract was determined by using the reducing power, nitric oxide and total antioxidant capacity assays. Results: The aqueous extract exerted significant (P < 0.05) curative and prophylactic antimalarial activities. The D/M extract exhibited significant curative (P < 0.05) but not prophylactic antiplasmodial effect. The aqueous extract exhibited in vitro antioxidant property with IC50's of (0.930 ± 0.021) mg/mL, (0.800 ± 0.001) mg/mL and (0.22 ± 0.05) mg/mL in the total antioxidant capacity, reducing power and nitric oxide assays. Histo- logical assessment of the liver of aqueous and D/M treated animals did not reveal any sign of toxicity. Conclusions: H. barteri is not toxic which exerted significant curative antiplasmodial effects but the prophylactic property was however fraction dependent. The mechanism of the antiplasmodial activity of H. barteri may partly be mediated by its antioxidant property. en_US
dc.language.iso en en_US
dc.publisher University of Cape Coast en_US
dc.subject Malaria en_US
dc.subject Parasitemia en_US
dc.subject Haematostaphis barteri en_US
dc.subject Antioxidants en_US
dc.subject Phytochemicals en_US
dc.title In vivo antiplasmodial and in vitro antioxidant properties of stem bark extracts of Haematostaphis barteri en_US
dc.type Article en_US


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